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MK-886

MK-886 Structure
CAS No.
118414-82-7
Chemical Name:
MK-886
Synonyms
MK866;MK-886;CS-1988;CGS-81585;L-663,536;MK-886 (Base);MK-886 (L-663,536);MK-886 (Free Base);3-[1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid;3-[3-tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid
CBNumber:
CB8671381
Molecular Formula:
C27H34ClNO2S
Molecular Weight:
472.08
MOL File:
118414-82-7.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
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MK-886 Properties

Melting point 295-297°C
storage temp. Sealed in dry,2-8°C
solubility DMSO: 32 mg/mL
form White solid.
color white
Stability Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

SAFETY

Risk and Safety Statements

WGK Germany  3

MK-886 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 475889 MK-886 - CAS 118414-82-7 - Calbiochem A cell-permeable, orally active NSAID that blocks cellular Cox pathway PGE2 production by inhibiting COX-1 and mPGES-1, but not COX-2, activity, as we 118414-82-7 5MG ₹16670.01 2022-06-14 Buy
Product number Packaging Price Buy
475889 5MG ₹16670.01 Buy

MK-886 Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

MK-886 is a potent and selective inhibitor of FLAP and Cox-1.

Definition

ChEBI: A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at pos tion 2. It acts as an inhibitor of arachidonate 5-lipoxygenase.

Biological Activity

An inhibitor of leukotriene biosynthesis (IC 50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC 50 = 30 nM for inhibition of [ 125 I]-L-691,678 photoaffinity labelling). Also moderately potent PPAR α antagonist (IC 50 = 0.5-1 μ M). Orally active in vivo .

MK-886 Preparation Products And Raw materials

Raw materials

Preparation Products

MK-886 Suppliers

Global( 141)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Wuhan Jingkang en Biomedical Technology Co., Ltd +8613720134139 China 4692 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 58
Amadis Chemical Company Limited 58

MK-886 Spectrum

MK-886(118414-82-7)1HNMR

118414-82-7(MK-886)Related Search:

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Fatostatin A JNJ 1661010 NAGLY MK-886,MK 886 SODIUM SALT,mk-886 sodium hydrate,MK-886 hydrate sodium salt
MK-886
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L-663,536 1-[(4-CHLOROPHENYL)METHYL]-3-[(1,1-DIMETHYLETHYL)THIO]-ALPHA,ALPHA-DIMETHYL-5-(1-METHYLETHYL)-1H-INDOLE-2-PROPANOIC ACID MK-886 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid 3-[3-tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid CGS-81585 3-[1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid 1H-Indole-2-propanoic acid, 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)- 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoicacid 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-diMethylpropanoic acid MK-886 (Free Base) MK-886 (L-663,536) 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid MK866 CS-1988 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)- leukotriene,FLAP,5-LOX,5-LO activating protein,non-competitive,L-663536,L663536,keratin-1,Leukotriene Receptor,Inhibitor,biosynthesis,Peroxisome proliferator-activated receptors,PPAR,PPARα,Apoptosis,MK 886,MK-886,inhibit MK-886 (Base) 118414-82-7 C27H34ClNO2S All Inhibitors Inhibitors Prostanoid receptor and related