Trandolapril
- CAS No.
- 87679-37-6
- Chemical Name:
- Trandolapril
- Synonyms
- Mavik;Odrik;Odric;Udrik;Gopten;Preran;ru44570;Trantowa;Ccris 6594;Olivetolic
- CBNumber:
- CB8682356
- Molecular Formula:
- C24H34N2O5
- Molecular Weight:
- 430.54
- MOL File:
- 87679-37-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/25 13:42:50
| Melting point | 122-123°C |
|---|---|
| Boiling point | 626.0±55.0 °C(Predicted) |
| Density | 1.181±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | white powder |
| pka | 3.15±0.20(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 87679-37-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360D | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NL6015178 | |||||||||
| HS Code | 2933995300 | |||||||||
| NFPA 704 |
|
Trandolapril price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T4827 | Trandolapril ≥98% (HPLC), white, powder | 87679-37-6 | 10MG | ₹16259.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T4827 | Trandolapril ≥98% (HPLC), white, powder | 87679-37-6 | 50MG | ₹64939.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3146 | Trandolapril pharmaceutical secondary standard, certified reference material | 87679-37-6 | 250MG | ₹18380.85 | 2022-06-14 | Buy |
Trandolapril Chemical Properties,Uses,Production
Description
Trandolapril is a new ACE inhibitor that is rapidly hydrolyzed, mainly in the liver, to its biologically active form, trandolaprilat. Compared with all other ACE inhibitors, trandolaprilat is reported to have the highest lipophilicity and the most prolonged ACE inhibitory activity. In hypertensive patients, trandolapril at a dose of 2 mg reduces blood pressure consistently throughout the 24 hour period after intake, making it one of the best once a day antihypertensive drugs. It has also been demonstrated to inhibit aortic atherosclerosis in the hyperlipidemic rabbit.
Chemical Properties
White or almost white powder.
Uses
Trandolapril has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on responsiveness of human retinal endothelial cells (HRECs) to vascular endothelial growth factor (VEGF).
General Description
Trandolapril, 1-[2-(1-ethoxycarbonyl-3-phenylpropylamino)propionyl]octahydroindole-2-carboxylicacid (Mavik), is an indole-containing ACE inhibitorthat is structurally related to most of the precedingagents discussed. Enalapril is very similar to trandolapril,with the primary difference occurring in the heterocyclicsystems. The pyrrolidine of enalapril has been replacedwith an octahydroindole system. Much like enalaprilate,trandolapril must be hydrolyzed to tranolaprilate, which isthe bioactive species.
Trandolapril Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 203)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Lupin Ltd | +91-8019896181 +91-8019896181 | Maharashtra, India | 93 | 58 | Inquiry |
| Glenmark Pharmaceuticals Limited | +912240189999 | Maharashtra, India | 93 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| AUROBINDO PHARMA LTD | +91 (40) 6672 1200 | New Delhi, India | 209 | 58 | Inquiry |
| GLENMARK LIFE SCIENCES LTD | +91 22 4018 9999 | New Delhi, India | 103 | 58 | Inquiry |
| LUPIN LTD | +91 124 4885000 / +91 124 3325000 | New Delhi, India | 191 | 58 | Inquiry |
| LUPIN LIMITED | 1800-399-2561 | New Delhi, India | 28 | 58 | Inquiry |
| VITALIFE LABORATORIES | +91 124 325 0624 | New Delhi, India | 10 | 58 | Inquiry |
| AUROBINDO PHARMA LIMITED | +91 (40) 6672 1200 | New Delhi, India | 144 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Lupin Ltd | 58 |
| Glenmark Pharmaceuticals Limited | 58 |
| Hetero Drugs Limited | 58 |
| AUROBINDO PHARMA LTD | 58 |
| GLENMARK LIFE SCIENCES LTD | 58 |
| LUPIN LTD | 58 |
| LUPIN LIMITED | 58 |
| VITALIFE LABORATORIES | 58 |
| AUROBINDO PHARMA LIMITED | 58 |
| CLEARSYNTH LABS LTD. | 58 |
87679-37-6(Trandolapril)Related Search:
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(2s-(1(r*(r*)),2-alpha,3a-alpha,7a-beta))-)amino)-1-oxopropyl)
ru44570
(2s,3ar,7as)-1-[(2s)-2-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
Mavik, (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic acid
(3αR．7αS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropy]-(S)-alanyl]oetahydroindole-2(S)-carboxylic acid
TrandolaprilC24H34N205
Mavik, Odrik, Gopten, RU-44570
1H-Indole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aR,7aS)- (9CI)
1H-Indole-2-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, [2S-[1[R*(R*)],2a,3aa,7ab]]-
Gopten
Odrik
Trandolapril／(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic Acid
TRANDOLAPRIL
1H-Indole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1- oxopropyl)-, (2S-(1(R*(R*)),2-alpha,3a-alpha,7a-beta))
(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-3a,4,5,6,7,7a-hexahydro-2-indolinecarboxylic acid
(2S,3aR,7aS)-1-[(S)-N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]alanyl]octahydro-1H-indole-2-carboxylic acid
Odric
Trantowa
(2S,3Ar,7as)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester
1H-Indole-2-carboxylic acid, 1-((2S)-2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2S,3ar,7as)-
Ccris 6594
Trandolapril (125 mg)
(2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]-octahydro-1H-indole-2-carboxylic acid
Preran
Tarka(coMb. with verapaMil)
Udrik
(2S,3aR,7aS)-
1H-Indole-2-carboxylicacid,1-[(2S)-2-[[(1S)-
(2S,3aR,7aS)-1-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)octahydro-1H-indole-2-carboxylic acid
1H-Indole-2-carboxylicacid,1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]aMino]-1-oxopropyl]octahydro-,(2S,3aR,7aS)-
Trandolapril Ph. Eur.
Olivetolic
(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
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Trandolapril Solution, 100ppm
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Trandolapril (RU44570)
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Trandolapril
Trandolapril (1672687)
Mavik
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87679-37-6
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