4-formyl-3-methoxybenzonitrile
- CAS No.
- 21962-45-8
- Chemical Name:
- 4-formyl-3-methoxybenzonitrile
- Synonyms
- 4-forMyl-3-Methoxybenzonitrile;4-Cyaon-2-methoxybenzaldehyde;Finerenone Impurity 111;2-Methoxy-4-cyanobenzaldehyde;4-CYANO-2-METHOXYBENZALDEHYDE;4-Cyan0-2-methoxybenzaldehyde;4-Formyl-3-methoxybenzonitril;3-Formyl-3-methoxybenzonitrile;Benzonitrile, 4-formyl-3-methoxy-;Para-tert-Butyl Benzene Sulfonamide
- CBNumber:
- CB8684633
- Molecular Formula:
- C9H7NO2
- Molecular Weight:
- 161.16
- MOL File:
- 21962-45-8.mol
- Modify Date:
- 2025/3/12 7:03:40
| Melting point | 109-111℃ |
|---|---|
| Boiling point | 318℃ |
| Density | 1.18 |
| vapor pressure | 0.003-2.3Pa at 20-80℃ |
| Flash point | 138℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| InChI | InChI=1S/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3 |
| InChIKey | ZXENVSJZOHXCKL-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC=C(C=O)C(OC)=C1 |
| LogP | 1.42 at 20℃ and pH7 |
4-formyl-3-methoxybenzonitrile Chemical Properties,Uses,Production
Uses
4-formyl-3-methoxybenzonitrile is a Finerenone intermediate compound. Finerenone is a non-steroidal salicorticosteroid receptor antagonist used to reduce the risk of serious kidney and heart problems in patients with chronic kidney disease associated with type 2 diabetes.
Synthesis
79 g (370 mmol) of sodium metaperiodate are added in portions to a vigorously stirred solution of 48 g (185 mmol) of tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate, 207 mg (0.81 mmol) of osmium tetroxide and 1.4 g (6.14 mmol) of benzyltriethylammonium chloride in 750 ml of water/THF (2:1), keeping the reaction temperature below 30° C. The solution is stirred at RT for a further 1 h. Water (2000 ml) is added, and the mixture is filtered. The remaining solid is dissolved in ethyl acetate and washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is stirred with petroleum ether. 21.18 g (71% of theory) of 4-cyano-2-methoxybenzaldehyde (4-formyl-3-methoxybenzonitrile) is obtained as a white solid.
4-formyl-3-methoxybenzonitrile Preparation Products And Raw materials
Raw materials
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| Supplier | Advantage |
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| SYNIX LABS | 58 |
| SCINTELLI | 58 |
| GMFC LABS PVT LTD | 58 |
| JAY CHEMICALS | 58 |
| MANVI BIOPHARMA PVT LTD, | 58 |
| ENANTI LABS PVT LTD | 58 |
| Synaptics Labs Private Limited | 58 |
| Rui Laboratories Pvt Ltd | 58 |
| Prodev Pharma Pvt Ltd | 58 |
| VCS Chem Tech Pvt Ltd | 58 |