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4-CYANO-2-METHOXYBENZALDEHYDE

4-CYANO-2-METHOXYBENZALDEHYDE Structure
CAS No.
21962-45-8
Chemical Name:
4-CYANO-2-METHOXYBENZALDEHYDE
Synonyms
4-forMyl-3-Methoxybenzonitrile;4-Cyaon-2-methoxybenzaldehyde;2-Methoxy-4-cyanobenzaldehyde;4-CYANO-2-METHOXYBENZALDEHYDE;4-Cyan0-2-methoxybenzaldehyde;4-Formyl-3-methoxybenzonitril;3-Formyl-3-methoxybenzonitrile;Benzonitrile, 4-formyl-3-methoxy-;4-Cyano-2-neneneba methoxy Benzaldehyde;4-CYANO-2-METHOXYBENZALDEHYDE,Finerenone
CBNumber:
CB8684633
Molecular Formula:
C9H7NO2
Molecular Weight:
161.16
MOL File:
21962-45-8.mol
Modify Date:
2024/4/29 14:28:21

4-CYANO-2-METHOXYBENZALDEHYDE Properties

Melting point 109-111℃
Boiling point 318℃
Density 1.18
vapor pressure 0.003-2.3Pa at 20-80℃
Flash point 138℃
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
InChI InChI=1S/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3
InChIKey ZXENVSJZOHXCKL-UHFFFAOYSA-N
SMILES C(#N)C1=CC=C(C=O)C(OC)=C1
LogP 1.42 at 20℃ and pH7

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xi
Risk Statements  43
Safety Statements  36/37
HS Code  2926907090

4-CYANO-2-METHOXYBENZALDEHYDE Chemical Properties,Uses,Production

Synthesis

79 g (370 mmol) of sodium metaperiodate are added in portions to a vigorously stirred solution of 48 g (185 mmol) of tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate, 207 mg (0.81 mmol) of osmium tetroxide and 1.4 g (6.14 mmol) of benzyltriethylammonium chloride in 750 ml of water/THF (2:1), keeping the reaction temperature below 30° C. The solution is stirred at RT for a further 1 h. Water (2000 ml) is added, and the mixture is filtered. The remaining solid is dissolved in ethyl acetate and washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is stirred with petroleum ether. 21.18 g (71% of theory) of 4-cyano-2-methoxybenzaldehyde is obtained as a white solid.
4-CYANO-2-METHOXYBENZALDEHYDE

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4-CYANO-2-METHOXYBENZALDEHYDE 2-Methoxy-4-cyanobenzaldehyde 4-ForMyl-3-Methoxybenzonitrile(2-Methoxy-4-cyanobenzaldehyde) Benzonitrile, 4-formyl-3-methoxy- 4-Cyaon-2-methoxybenzaldehyde 4-forMyl-3-Methoxybenzonitrile 4-Formyl-3-methoxybenzonitrile (or) 4-Cyano-2-Methoxy Benzaldehyde 4-Cyano-2-neneneba methoxy Benzaldehyde 4-Cyan0-2-methoxybenzaldehyde 4-CYANO-2-METHOXYBENZALDEHYDE,Finerenone 3-Formyl-3-methoxybenzonitrile 4-Formyl-3-methoxybenzonitril 21962-45-8 Intermediate 21962-45-8