4-Bromo-2-hydroxybenzoic acid
- CAS No.
- 1666-28-0
- Chemical Name:
- 4-Bromo-2-hydroxybenzoic acid
- Synonyms
- NSC 109120;4-BROMOSALICYLIC ACID;4-Bromosalicyclic acid;4-Bromosalicylic acid, >=98%;2-Hydroxy-4-bromobenzoicacid;4-bromo-2-hydoxybenzoic acid;4-BROMO-2-HYDROXYBENZOIC ACID;VLOOKUP(C4,[1]Export!$D:$H,5,0);Benzoicacid, 4-bromo-2-hydroxy-;4-Bromo-2-hydroxybenzoic acid 98%
- CBNumber:
- CB4196824
- Molecular Formula:
- C7H5BrO3
- Molecular Weight:
- 217.02
- MOL File:
- 1666-28-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
| Melting point | 164-165°C |
|---|---|
| Boiling point | 330.2±32.0 °C(Predicted) |
| Density | 1.861±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 2.71±0.10(Predicted) |
| form | powder |
| color | Orange |
| InChI | InChI=1S/C7H5BrO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,(H,10,11) |
| InChIKey | FYAKLZKQJDBBKW-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(Br)C=C1O |
| CAS DataBase Reference | 1666-28-0(CAS DataBase Reference) |
4-Bromo-2-hydroxybenzoic acid Chemical Properties,Uses,Production
Chemical Properties
4-Bromo-2-hydroxybenzoic acid is a solid at normal temperature and pressure. It is stable at normal temperature and decomposes into phenol and carbon dioxide after rapid heating. It has some acidic properties.
Uses
2-Hydroxy-4-bromobenzoic acid is used as an anti-scorch agent in drug molecules and rubber industry, as well as an intermediate in the production of ultraviolet absorbers and foaming agents.
Synthesis
Under nitrogen atmosphere, add copper (II) bromide (8.8 g, 39.4 mmol, 1.2 equivalents), acetonitrile (50 ml), and 4-aminosalicylic acid (5.1 g, 49.5 mmol) to the vacuum-dried reaction flask, 1.5 equivalent). The reaction mixture was cooled to 0°C, and 2-hydroxy-4-bromobenzoic acid precursor (5.0 g, 32.6 mmol, 1.0 equiv) was added portion-wise. Additional acetonitrile (25 mL) was added to the mixture and stirred at 0 °C for 2 h. The organic extracts were combined and washed with 20% aqueous hydrochloric acid, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was dissolved in diethyl ether, and the resulting solution was extracted with 15% sodium hydroxide aqueous solution. The aqueous solution was washed with diethyl ether, acidified to pH 1 with 6N hydrochloric acid aqueous solution, and the mixture was extracted with diethyl ether. The combined organic extracts were washed with brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was treated with chloroform, and the precipitate collected by filtration was 4-Bromo-2-hydroxybenzoic acid.
4-Bromo-2-hydroxybenzoic acid Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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| BASR Fine Chemicals Pvt. Ltd. | +91-9848230391 +91-9848230391 | Telangana, India | 908 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29897 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | China | 10297 | 58 | Inquiry |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | CHINA | 21149 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 11718 | 58 | Inquiry |
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