2-Nitrophenol
- CAS No.
- 88-75-5
- Chemical Name:
- 2-Nitrophenol
- Synonyms
- O-NITROPHENOL;o-Nitrofenol;Nsc 1552;2-NITROPHENOL;2-nitro-pheno;o-nitro-pheno;2-Nitrylphemol;Phenol,2-nitro-;Phenol, o-nitro-;o-nitrophenol[qr]
- CBNumber:
- CB3854576
- Molecular Formula:
- C6H5NO3
- Molecular Weight:
- 139.11
- MOL File:
- 88-75-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/10/21 10:57:28
| Melting point | 43-45 °C |
|---|---|
| Boiling point | 214-216 °C |
| Density | 1.495 |
| vapor pressure | 1 mm Hg ( 49.3 °C) |
| refractive index | 1.5723 |
| Flash point | 108 °C |
| storage temp. | Store in dark! |
| solubility | 2 g/L (25°C) |
| pka | 7.17(at 25℃) |
| form | Liquid |
| color | Clear pale yellow |
| PH Range | Colorless (5.0) to yellow (7.0) |
| PH | 5.0～7.0 |
| Odor | Aromatic odor |
| Water Solubility | 2 g/L (25 ºC) |
| Sensitive | Light Sensitive |
| Merck | 14,6619 |
| BRN | 775403 |
| Henry's Law Constant | At 20 °C: 11.1 at pH 8.1, 11.0 at pH 10.2, 8.9 at pH 11.9, 6.7 at pH 13.7 (wetted-wall column-UV, Zhang et al., 2003) |
| Stability | Stable. Incompatible with strong bases, strong oxidizing agents. |
| Major Application | High voltage capacitors, inks, energetic materials, corrosion inhibitors, fertilizer, food storage, enzyme assays, detecting microorganisms, immunotherapy, drugs |
| LogP | 1.77 |
| Dissociation constant | 7.23 at 25℃ |
| CAS DataBase Reference | 88-75-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenol, 2-nitro-(88-75-5) |
| EPA Substance Registry System | o-Nitrophenol (88-75-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H410 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-36/37/38-52/53-33-20/21/22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 26-61-45-36/37-16-7-36-28 | |||||||||
| RIDADR | UN 1663 6.1/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | SM2100000 | |||||||||
| Autoignition Temperature | 550 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29089000 | |||||||||
| Toxicity | LD50 orally in mice, rats: 1.297, 2.828 g/kg, K. C. Back et al., Reclassification of Materials Listed as Transportation Health Hazards (TSA-20-72-3; PB214-270, 1972) | |||||||||
| NFPA 704 |
|
2-Nitrophenol price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N19702 | 2-Nitrophenol 98% | 88-75-5 | 5G | ₹2208.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N19702 | 2-Nitrophenol 98% | 88-75-5 | 100G | ₹5986.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N19702 | 2-Nitrophenol 98% | 88-75-5 | 500G | ₹8984.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N19702 | 2-Nitrophenol 98% | 88-75-5 | 1KG | ₹11939.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.06790 | 2-Nitrophenol for synthesis | 88-75-5 | 100G | ₹5340.01 | 2022-06-14 | Buy |
2-Nitrophenol Chemical Properties,Uses,Production
Chemical Properties
yellow crystalline solid
Uses
2-Nitrophenol is an intermediate in dyestuff production and a chemical indicator.
Definition
ChEBI: A member of the class of 2-nitrophenols that is phenol in which one of the hydrogens that is ortho to the hydroxy group has been replaced by a nitro group.
Production Methods
2-Chloronitrobenzene in 8.5 % sodium hydroxide solution is heated gradually (exothermic) to 170 ℃ in an autoclave and held there under pressure for 8 h. The resulting solution is cooled and acidified to give the product 2-Nitrophenol in 95 % yield.
General Description
Yellow solid. Sinks in and mixes slowly with water.
Air & Water Reactions
Water insoluble.
Reactivity Profile
2-Nitrophenol is a yellow, crystalline material, moderately toxic, low melting point (45° C). When heated to decomposition 2-Nitrophenol emits toxic fumes of oxides of nitrogen. In molten form violent reaction with strong alkali (85 % potassium hydroxide) [491 M, 1975, p. 342]. Reaction product with chlorosulfuric acid decomposes violently at room temperature [Vervalin, C. H., Hydrocarbon Proc., 1976, 55(9), p. 321].
Hazard
Toxic by ingestion.
Health Hazard
Inhalation or ingestion causes headache, drowsiness, nausea, and blue color in lips, ears, and fingernails (cyanosis). Contact with eyes causes irritation. Can be absorbed through the intact skin to give same symptoms as for inhalation.
Fire Hazard
Special Hazards of Combustion Products: Toxic and irritating fumes of unburned material and oxides of nitrogen can form in fire.
Purification Methods
Crystallise 2-nitrophenol from EtOH/water, water, EtOH, *benzene or MeOH/pet ether (b 70-90o). It can be steam distilled. Petrucci and Weygandt [Anal Chem 33 275 1961] crystallised it from hot water (twice), then EtOH (twice), followed by fractional crystallisation from the melt (twice), drying over CaCl2 in a vacuum desiccator and then in a drying pistol. The 4-nitrobenzoate had m 141o (from EtOH). [Beilstein 6 IV 1246.]
2-Nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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