6-Biopterin
- CAS No.
- 22150-76-1
- Chemical Name:
- 6-Biopterin
- Synonyms
- BIOPTERIN;L-BIOPTERIN;pterinhb2;NSC-339699;6-BIOPTERIN;6-Biopterin, ≥97%;D-erythro-Biopterin;L-erythro-Biopterin;(1'R,2'S)-BIOPTERIN;L-Biopterin(6-Biopterin)
- CBNumber:
- CB8691190
- Molecular Formula:
- C9H11N5O3
- Molecular Weight:
- 237.22
- MOL File:
- 22150-76-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:03
| Melting point | >210°C dec. |
|---|---|
| alpha | D24 -50° (c = 0.4 in 0.1N HCl); D24 -26° (c = 0.92 in 0.1N NaOH) |
| Boiling point | 379.74°C (rough estimate) |
| Density | 1.3472 (rough estimate) |
| refractive index | 1.7610 (estimate) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly, Heated, Sonicated) |
| form | White to pale yellow powder. |
| pka | 13.18±0.20(Predicted) |
| color | White to Light Yellow |
| Merck | 13,1229 |
| BRN | 87860 |
| Stability | Hygroscopic |
| CAS DataBase Reference | 22150-76-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | UO3506000 |
| F | 10-23 |
| HS Code | 29339900 |
| Toxicity | sln-par-dmg 10 mg/L MUREAV 128,147,84 |
6-Biopterin price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B2517 | 6-Biopterin ≥97% | 22150-76-1 | 5MG | ₹8735.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B2517 | 6-Biopterin ≥97% | 22150-76-1 | 25MG | ₹33211.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B2517 | 6-Biopterin ≥97% | 22150-76-1 | 50MG | ₹59104.5 | 2022-06-14 | Buy |
6-Biopterin Chemical Properties,Uses,Production
Description
6-Biopterin (L-Biopterin) is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 μM after 48 hrs). L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.
Chemical Properties
Crystalline Solid
Uses
L-Biopterin is a pteridine widely distributed in nature; naturally occurring as the L-erythro-form. Considered as a growth factor for some insects. Fluoresces with a blue color in alkaline solution.
Definition
6-Biopterin is an enzymatic cofactor derived from pterin and involved in certain oxidation-reduction reactions. It is a biopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form. It is an enantiomer of a D-erythro-biopterin.
Application
6-Biopterin is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). In vitro, 6-Biopterin is cytotoxic to melanocytes. However, in vivo, 6-Biopterin is rapidly and sequentially reduced back to 6-GH4 via q-BH2. Recent studies suggest that 6-Biopterin among other pteridines may be a useful non-invasive biomarker for cancer.
Preparation
Biopterin is synthesized by reacting 2,4,5-triamino-6-hydroxypyrimidine with 5-deoxy-L-arabinosone in aqueous solution at pH of about 7.5 to 10, acidifying and then recrystallizing by dissolving in basic solution and precipitating with acid. 5-deoxy-L-arabinosone is prepared by oxidizing S-deoxy-L-arabinose, which is prepared from L-rhamnose, using cupric acetate.
Process for the synthesis of biopterin
Safety Profile
Moderately toxic by ingestion andintraperitoneal routes. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx.
6-Biopterin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt., Ltd. | 91-22-40560560 | Maharashtra, India | 91 | 58 | Inquiry |
| Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group) | 91-22-42361111 | Maharashtra, India | 147 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
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