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DIMETHISTERONE

DIMETHISTERONE Structure
CAS No.
79-64-1
Chemical Name:
DIMETHISTERONE
Synonyms
Ovin;P 5048;Lutogan;Secrosteron;DIMETHISTERONE;DIMETHISTERONE USP/EP/BP;6α,21-Dimethylethisterone;6α-Methyl-17-(1-propynyl)testosterone;17β-Hydroxy-6α-methyl-17-(1-propynyl)androst-4-en-3-one;Androst-4-en-3-one,17-hydroxy-6-methyl-17-(1-propynyl)-, (6a,17b)-
CBNumber:
CB8702265
Molecular Formula:
C23H32O2
Molecular Weight:
340.5
MOL File:
79-64-1.mol
MSDS File:
SDS
Modify Date:
2023/5/15 10:43:13

DIMETHISTERONE Properties

Melting point 102°
alpha D20 +10° (c = 1 in chloroform)
Boiling point 416.28°C (rough estimate)
Density 1.0555 (rough estimate)
refractive index 1.4480 (estimate)
pka 13.03±0.70(Predicted)
EPA Substance Registry System Dimethisterone (79-64-1)

DIMETHISTERONE Chemical Properties,Uses,Production

Originator

Oracon,Mead Johnson,US,1965

Manufacturing Process

A solution of a Grignard reagent, employing 1-propyne (8 grams) was prepared. To this reagent there was added the 3,3 ethylenedioxy derivative (4 grams) of 6-α-methylandrost-4-ene-3,17-dione in tetrahydrofuran (100 ml), and the mixture heated under reflux for 3 hours. After decomposition of the complex with aqueous ammonium chloride, the product was isolated with ether and treated with 90% acetic acid (50 ml) for 30 minutes at 100°C. The product obtained by pouring the mixture into water and extracting with ether was crystallized from aqueous methanol. 17β-Hydroxy-6α-methyl-17α-(prop- 1-ynyl)androst-4-en-3-one formed plates MP 99° to 102°C.

Therapeutic Function

Progestin

DIMETHISTERONE Preparation Products And Raw materials

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DIMETHISTERONE 17β-Hydroxy-6α-methyl-17-(1-propynyl)androst-4-en-3-one 6α,21-Dimethylethisterone Lutogan Ovin P 5048 Secrosteron 6α-Methyl-17-(1-propynyl)testosterone (6S,8R,9S,10R,13S,14S,17S)-17-hydroxy-6,10,13-trimethyl-17-prop-1-ynyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one DIMETHISTERONE USP/EP/BP Androst-4-en-3-one, 17-hydroxy-6-methyl-17-(1-propynyl)-, (6α,17β)- Androst-4-en-3-one,17-hydroxy-6-methyl-17-(1-propynyl)-, (6a,17b)- 79-64-1