SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE
![SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Structure](CAS/GIF/125494-59-9.gif)
- CAS No.
- 125494-59-9
- Chemical Name:
- SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE
- Synonyms
- SIBUTRAMINE HCL MONOHYDRATE;Sibutramine sib;SibutramineHClH2O;SIBUTRAMINE HCL HYDRATE;)-SibutraMine-d6 HCl H2O;BTS-54524, Reductil, Meridia;SIBUTRAMINE HYDROCHLORIDE HYDRATE;Sibutramine hydrochloride solution;Sibutramine Hydrochloride Monohydra;SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE
- CBNumber:
- CB8708494
- Molecular Formula:
- C17H29Cl2NO
- Molecular Weight:
- 334.32
- MOL File:
- 125494-59-9.mol
- Modify Date:
- 2023/4/23 13:52:06
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() GHS02,GHS06,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H225-H301+H311+H331-H370 |
Precautionary statements | P210-P260-P280-P301+P310-P311 |
Hazard Codes | Xi,T,F |
Risk Statements | 36/37/38-39/23/24/25-23/24/25-11 |
Safety Statements | 22-24/25-36-26-45-36/37-16-7 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 3 |
SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Chemical Properties,Uses,Production
Description
Sibutramine was introduced as Meridia in the US for the control of obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by creating a satieted feeling and increases energy expenditure by enhancing thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of Sibutramine once-daily, meaningful weight loss was sustained for 12 months ; an additional study demonstrated a lack of abuse potential. An appreciable part of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites, which are very potent monoamine reuptake inhibitors themselves.
Chemical Properties
White Solid
Uses
A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure