ARG-GLY-ASP-SER

ARG-GLY-ASP-SER Structure
CAS No.
91037-65-9
Chemical Name:
ARG-GLY-ASP-SER
Synonyms
RGDS;RGDS peptide;ARG-GLY-ASP-SER;RGDS 1/2ACOH 2H2O;L-ARG-GLY-ASP-SER;Arg-Gly-Asp-Ser-OH;H-ARG-GLY-ASP-SER-OH;RGDS/ARG-GLY-ASP-SER;FIBRONECTIN INHIBITOR;Arg-Gly-Asp-Ser, >=98%
CBNumber:
CB9117206
Molecular Formula:
C15H27N7O8
Molecular Weight:
433.42
MOL File:
91037-65-9.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:39

ARG-GLY-ASP-SER Properties

Melting point 183-187℃
Density 1.65±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility ≥21.65 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO
form White to off-white powder
pka 2.84±0.10(Predicted)
color White to off-white
Water Solubility Soluble in water at 1mg/ml
Sequence H-Arg-Gly-Asp-Ser-OH

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

ARG-GLY-ASP-SER price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A9041 Arg-Gly-Asp-Ser ≥95% (HPLC) 91037-65-9 2MG ₹8151.23 2022-06-14 Buy
Sigma-Aldrich(India) A9041 Arg-Gly-Asp-Ser ≥95% (HPLC) 91037-65-9 5MG ₹14743.65 2022-06-14 Buy
Sigma-Aldrich(India) A9041 Arg-Gly-Asp-Ser ≥95% (HPLC) 91037-65-9 10MG ₹27019.2 2022-06-14 Buy
Sigma-Aldrich(India) 03-34-0002 H-Arg-Gly-Asp-Ser-OH - CAS 91037-65-9 - Calbiochem 91037-65-9 25MG ₹18980 2022-06-14 Buy
Product number Packaging Price Buy
A9041 2MG ₹8151.23 Buy
A9041 5MG ₹14743.65 Buy
A9041 10MG ₹27019.2 Buy
03-34-0002 25MG ₹18980 Buy

ARG-GLY-ASP-SER Chemical Properties,Uses,Production

Uses

Arg-Gly-Asp-Ser has been used:

  • to study its effects on cell attachment in rats
  • to analyse the interaction of fibrinogen with erythrocytes occurs through integrin related receptor
  • to pretreat the cells, to assess the role of integrin in the cell attachment process
  • to test its competition with platelet-secreted, nanosheet-adsorbed proteins for binding to glycoprotein IIIa (GPIIIa)

General Description

The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.

RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor ?1 (TGF?1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated
to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages

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ARG-GLY-ASP-SER Spectrum

Fibronectin tetrapeptide L-Arginylglycyl-L-alpha-aspartyl-L-serine L-Serine, L-arginylglycyl-L-alpha-aspartyl- L-Serine, N-(N-(N-L-arginylglycyl)-L-alpha-aspartyl)- arginyl-glycyl-aspartyl-serine RGDS RGDS 1/2ACOH 2H2O L-Serine,N-[N-(N-L-arginylglycyl)-L-a-aspartyl]- L-Serine,L-arginylglycyl-L-a-aspartyl- Arg-Gly-Asp-Ser, >=98% RGDS PEPTIDE;FIBRONECTIN INHIBITOR L-ARG-GLY-ASP-SER H-ARG-GLY-ASP-SER-OH FIBRONECTIN ATTACHMENT PEPTIDE ARG-GLY-ASP-SER ARG-GLY-ASP-SER 1/2ACOH 2H2O RGDS/ARG-GLY-ASP-SER Arg-Gly-Asp-Ser-OH L-Arg-Gly-L-Asp-L-Ser-OH RGDS peptide FIBRONECTIN INHIBITOR H-Arg-Gly-Asp-Ser-OH - CAS 91037-65-9 - Calbiochem Arg-Gly-Asp-Ser, ≥95%(HPLC) L-Serine, L-arginylglycyl-L-α-aspartyl- 91037-65-9 C15H27N7O8 Extracellular Matrix Peptides and Proteins Extracellular Matrix BioChemical Cell Signaling and Neuroscience Cell Biology Cytoskeleton and Extracellular Matrix Peptide Cell Signaling Enzymes ECM ProteinsCytoskeleton and Extracellular Matrix Extracellular Matrix Extracellular Matrix Peptides (ECM) Extracellular Matrix Peptides and ProteinsPeptides for Cell Biology Fibronectin Fragments and Analogs Matrix Metalloproteinases Products Various Peptides RGD