DIISOPROPYL FLUOROPHOSPHATE
- CAS No.
- 55-91-4
- Chemical Name:
- DIISOPROPYL FLUOROPHOSPHATE
- Synonyms
- DFP;DIFP;tl466;Dyflos;ea1152;T-1703;TL 466;EA 1152;Diflupyl;Floropryl
- CBNumber:
- CB9168071
- Molecular Formula:
- C6H14FO3P
- Molecular Weight:
- 184.15
- MOL File:
- 55-91-4.mol
- Modify Date:
- 2023/5/4 17:34:40
| Melting point | −82 °C(lit.) |
|---|---|
| Boiling point | 62 °C9 mm Hg(lit.) |
| Density | 1.06 g/mL at 25 °C(lit.) |
| vapor pressure | 0.58 mm Hg ( 20 °C) |
| refractive index |
n |
| storage temp. | 2-8°C |
| solubility | Benzene (Slightly) |
| form | Oil |
| color | Colourless to Light Yellow |
| Specific Gravity | 1.055 (25℃/4℃) |
| Water Solubility | 15.17g/L(25 ºC) |
| Merck | 13,5194 |
| Stability | Stable. Moisture sensitive. |
| CAS DataBase Reference | 55-91-4(CAS DataBase Reference) |
| EPA Substance Registry System | Diisopropyl fluorophosphate (55-91-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H330-H310-H300 |
| Precautionary statements | P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501 |
| Hazard Codes | T+,Xi |
| Risk Statements | 26/27/28-36/37/38 |
| Safety Statements | 36/37/39-45-36/37-26 |
| RIDADR | UN 3382 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | TE5075000 |
| F | 10-21 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 29209085 |
| Toxicity | LD50 in mice (mg/kg): 3.71 s.c.; 36.8 orally (Horton) |
DIISOPROPYL FLUOROPHOSPHATE Chemical Properties,Uses,Production
Chemical Properties
Colourless Liquid
Uses
Diisopropyl Fluorophosphate is a potent inhibitor of serine proteases such as trypsin and chymotrypsin, and of acetylcholinesterase. Diisopropyl fluorophosphate is a very potent neurotoxin.
General Description
Oily liquid. Clear, colorless or faintly yellow liquid. DIISOPROPYL FLUOROPHOSPHATE is used as a research tool in neuroscience for its ability to inhibit cholinesterase (by phosphorylation) on an acute/sub-acute basis and to produce a delayed neuropathy. An insecticide. Used in Germany as a basis for "nerve gases".
Air & Water Reactions
Forms hydrogen fluoride in presence of moisture; decomposes in water at pH about 2.5.
Reactivity Profile
Organophosphates, such as DIISOPROPYL FLUOROPHOSPHATE, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Health Hazard
This is an organophosphate pesticide. Extremely toxic: probable oral lethal dose in humans is 5-50 mg/kg, between 7 drops and 1 teaspoonful for 70 kg person (150 lb.). The material is a cholinesterase inactivator. Even traces of the vapor cause pinpoint pupils.
Fire Hazard
May burn but will not ignite readily. Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Forms hydrogen fluoride in presence of moisture; decomposes in water at pH about 2.5. Keep away from sources of heat. Anhydrous compounds or oil solutions are stable in glass containers at room temperature.
Waste Disposal
It is dissolved in a combustible solvent and burned in a chemical incinerator. It may be destroyed by treating with molten metal at 800-1000°C (1472-1832°F). It may be decomposed by treatment with dilute acid. Care should be taken, as highly toxic HF may be generated.