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QUISQUALIC ACID

CAS No.: 52809-07-1

Chemical Name:: QUISQUALIC ACID

Synonyms: QUISQUALATE;QUISQUALIC ACID;L-QUISQUALIC ACID;(+)-QuisqualicAci;Quisqualinic acid;()-QUISQUALIC ACID;(+)-QUISQUALIC ACID;L(+)-QUISQUALIC ACID;Quisqualic acid (7CI);QUISQUALIC ACID USP/EP/BP

CBNumber:: CB9198500

Molecular Formula:: C5H7N3O5

Molecular Weight:: 189.13

MOL File:: 52809-07-1.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

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QUISQUALIC ACID Properties

Melting point	185-187°C dec.
alpha	D20 +17.0° (c = 2.0 in 6M HCl)
Boiling point	324.36°C (rough estimate)
Density	1.6649 (rough estimate)
refractive index	1.6190 (estimate)
storage temp.	2-8°C
solubility	NH₄OH 1 M: 20 mg/mL, clear, colorless
pka	2.12±0.10(Predicted)
form	powder
color	white to off-white
Water Solubility	Soluble in ethanol, water. Insoluble in organic solvents.
Merck	13,8177
BRN	1078734
Stability	Stable. Incompatible with strong oxidizing agents.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H332

Precautionary statements

P261-P280h-P301+P312a-P304+P340-P321-P501a

Hazard Codes

Risk Statements

20/21/22

Safety Statements

26-36

WGK Germany

NFPA 704

	0
3		0

QUISQUALIC ACID price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	Q2128	Quisqualic acid powder	52809-07-1	1MG	₹9515.18	2022-06-14	Buy
Sigma-Aldrich(India)	Q2128	Quisqualic acid powder	52809-07-1	5MG	₹30374.95	2022-06-14	Buy
Sigma-Aldrich(India)	Q2128	Quisqualic acid powder	52809-07-1	10MG	₹45952.13	2022-06-14	Buy
Sigma-Aldrich(India)	Q2128	Quisqualic acid powder	52809-07-1	25MG	₹103963.3	2022-06-14	Buy

Product number	Packaging	Price	Buy
Q2128	1MG	₹9515.18	Buy
Q2128	5MG	₹30374.95	Buy
Q2128	10MG	₹45952.13	Buy
Q2128	25MG	₹103963.3	Buy

QUISQUALIC ACID Chemical Properties,Uses,Production

Description

L-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC₅₀s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4; K_i = 6.43 nM). L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.

Chemical Properties

Off-White Solid

Uses

Quisqualic acid is used to differentiate between mGluR-1 and mGluR-4. L-Quisqualic acid is an activator of GluR.

General Description

Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.

Biological Activity

Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™ .

Purification Methods

It has been purified by ion-exchange chromatography on Dowex 50W (x 8, H+ form); the desired fractions are lyophilised and recrystallised from H2O/EtOH. It has IR (KBr) : 3400-2750br, 1830s, 1775s, 1745s and 1605s cm-1;maxand 1H NMR (NaOD/D2O, pH 13) : 3.55-3.57 (1H m, X of ABX, H-2), 3.72-3.85 (2H, AB of ABX, H-3), 1 3C NMR (D2O) : 50.1t, 53.4d, 154.8s, 159.7s and 171.3s. [Baldwin et al. J Chem Soc, Chem Commun 256 1985.] It is a quasiqualate receptor agonist [Joels et al. Proc Natl Acad Sci USA 86 3404 1989].

QUISQUALIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

QUISQUALIC ACID Suppliers

Global( 135)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	China	7034	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24722	58	Inquiry
Nextpeptide Inc	+86-0571-81612335 +8613336028439	China	19915	58	Inquiry
Labnetwork lnc.	+86-27-50766799 +8618062016861	China	19994	58	Inquiry
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	China	9425	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
career henan chemical co	58
Shanghai UCHEM Inc.	58
Dideu Industries Group Limited	58
Nextpeptide Inc	58
Labnetwork lnc.	58
Henan Aochuang Chemical Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

52809-07-1(QUISQUALIC ACID)Related Search:

4-Phosphonophenylglycine AIDA L-AP4 IBOTENIC ACID (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST

MPPG Albizziin 2,3-Diaminopropionic acid Hydroxyurea 3-(N-Methylamino)-L-alanine

QUISQUALIC ACID L-2,3-Diaminopropionic acid 3-UREIDOPROPIONIC ACID 1,2,4-OXADIAZOLIDINE-3,5-DIONE ALPHA-BENZYLQUISQUALIC ACID

[3H]QUISQUALIC ACID 2-(2-AMINO-ETHYL)-[1,2,4]OXADIAZOLIDINE-3,5-DIONE 1-Hydroxy-3-methylurea

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3-(3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL)-L-ALANINE L(+)-QUISQUALIC ACID L-QUISQUALIC ACID L-(+)-A-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID (L)-(+)-ALPHA-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID BETA-[3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL]-L-ALANINE BETA-(3,5-DIOXO-1,2,4-OXADIZOLIDIN-2-YL)-L-ALANINE (+)-QUISQUALIC ACID QUISQUALIC ACID L-(+)-a-Amino-3,5-Dioxo-1,2,4-oxadiazolidine-2-pro β-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)-l-alanine QUISQUALATE L-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic Acid β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine (S)-2-Amino-3-(3,5-dioxotetrahydro-1,2,4-oxadiazole-2-yl)propionic acid (αS)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid (αS)-α-Amino-3,5-dioxotetrahydro-1,2,4-oxadiazole-2-propionic acid Quisqualic acid,β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine (S)-2-aMino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid 1,2,4-Oxadiazolidine-2-propanoicacid, a-aMino-3,5-dioxo-, (aS)- ()-QUISQUALIC ACID 1,2,4-Oxadiazolidine-2-propanoic acid, α-amino-3,5-dioxo-, (αS)- (+)-QuisqualicAci QUISQUALIC ACID USP/EP/BP Quisqualinic acid Quisqualic acid (7CI) 52809-07-1 C5H7N3O5 Amino Acids and Peptides Biochemicals and Reagents BioChemical Cell Signaling and Neuroscience Cell Biology Modified Amino Acids Ligand-Gated Ion Channels I - Z Ionotropic Glutamate Receptor Modulators Ion Channels Heterocycles Glutamate Amino Acids 13C, 2H, 15N Amino Acids & Derivatives Neurochemicals Glutamate receptor