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Bafetinib

Bafetinib Structure
CAS No.
859212-16-1
Chemical Name:
Bafetinib
Synonyms
Benil;Ns 187;CS-239;Rhinon;Inno-406;Inno 406;Rinazina;Unii-nvw4Z03I9b;NS-187|||INNO-406;Bafetinib (INNO-406)
CBNumber:
CB92473854
Molecular Formula:
C30H31F3N8O
Molecular Weight:
576.62
MOL File:
859212-16-1.mol
MSDS File:
SDS
Modify Date:
2025/4/17 18:22:24
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Bafetinib Properties

Melting point 166-168°C
Density 1.36±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO:42.0(Max Conc. mg/mL);72.84(Max Conc. mM)
form A crystalline solid
pka 12.72±0.70(Predicted)
color Light yellow to yellow

Bafetinib Chemical Properties,Uses,Production

Description

Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia (CML). Bafetinib is a rationally developed tyrosine kinase inhibitor based on the chemical structure of imatinib , with modifications added to improve binding and potency against Bcr-Abl kinase (IC50 = 5.8 nM). It is 25- to 55-fold more potent than imatinib in vitro and ≥10-fold more potent in vivo. Bafetinib inhibits 12 out of the 13 most frequent imatinib-resistant Bcr-Abl point mutations, but not the T315I mutation and also targets the Src family kinase Lyn (IC50 = 19 nM), which has been associated with resistance to imatinib in CML.

Chemical Properties

Pale Yellow Solid

Uses

A substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). It was identified as highly potent Bcr-Abl kinase inhibitor.

Bafetinib Preparation Products And Raw materials

Raw materials

Preparation Products

Bafetinib Suppliers

Global( 119)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29859 58 Inquiry
Xiamen AmoyChem Co., Ltd +86-86-5926051114 +8615060885618 China 6383 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22854 58 Inquiry
Sinoway Industrial co., ltd. 0592-5800732; +8613806035118 China 987 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
career henan chemical co 58
Xiamen AmoyChem Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Sinoway Industrial co., ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58

859212-16-1(Bafetinib)Related Search:

Erlotinib Sunitinib Flumatinib mesylate Baricitinib Bortezomib
Bosutinib Nilotinib Vismodegib (GDC-0449) Trametinib Ibrutinib
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Benzamide, N-(3-((4,5'-bipyrimidin)-2-ylamino)-4-methylphenyl)-4-(((3S)-3-(dimethylamino)-1-pyrrolidinyl)methyl)-3-(trifluoromethyl)- Inno 406 Inno-406 4-[[(3S)-3-Dimethylaminopyrrolidin-1-yl]methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide Ns 187 Unii-nvw4Z03I9b Bafetinib (INNO-406) N-[3-([4,5'-BipyriMidin]-2-ylaMino)-4-Methylphenyl]-4-[[(3S)-3-(diMethylaMino)-1-pyrrolidinyl]Methyl]-3-(trifluoroMethyl)benzaMide Bafetinib(INNO 406,NS 187) (S)-N-(3-([4,5'-bipyriMidin]-2-ylaMino)-4-Methylphenyl)-4-((3-(diMethylaMino)pyrrolidin-1-yl)Methyl)-3-(trifluoroMethyl)benzaMide (S)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide Bafetinib N-[3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3-(dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzamide NS-187; BAFETINIB; INNO406 CS-239 INNO 406 - Bafetinib Benil Rhinon Rinazina NS-187|||INNO-406 Bafetinib, 10 mM in DMSO 859212-16-1 Aromatics Chiral Reagents Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals