Poly(1-vinylpyrrolidone-co-vinyl acetate)
- CAS No.
- 25086-89-9
- Chemical Name:
- Poly(1-vinylpyrrolidone-co-vinyl acetate)
- Synonyms
- VP/VA COPOLYMER;pvp-va;e335;kollidonva64;e535;s630;i535;i635;i735;kolima75
- CBNumber:
- CB9295023
- Molecular Formula:
- C10H15NO3
- Molecular Weight:
- 197.23
- MOL File:
- 25086-89-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/24 17:31:20
| Density | 1.27 g/mL at 25 °C(lit.) |
|---|---|
| Tg | 108 |
| refractive index | 1.4300 to 1.4380 |
| Flash point | 72 °F |
| solubility | Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane. |
| form | powder |
| color | White |
| Stability | Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents. |
| InChI | InChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3 |
| InChIKey | FYUWIEKAVLOHSE-UHFFFAOYSA-N |
| SMILES | C(N1CCCC1=O)=C.O(C=C)C(=O)C |
| LogP | 0.370 (est) |
| EPA Substance Registry System | Vinyl acetate N-vinyl-pyrrolidone polymer (25086-89-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 10-36/37/38-67-36-11-22 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26-16 | |||||||||
| RIDADR | UN 1987 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | AH3539000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 orl-rat: >630 mg/kg JACTDZ 2(5),141,83 | |||||||||
| NFPA 704 |
|
Poly(1-vinylpyrrolidone-co-vinyl acetate) price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 190845 | Poly(1-vinylpyrrolidone-co-vinyl acetate) average Mw ~50,000 (GPC vs. poly(ethylene oxide)), powder | 25086-89-9 | 250G | ₹14527.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 190837 | Poly(1-vinylpyrrolidone-co-vinyl acetate) solution average Mw ~13,000 (GPC vs. poly(ethylene oxide)), 50?wt. % in isopropanol | 25086-89-9 | 500G | ₹9396.1 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P0385 | Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 3:7) (50% in Ethanol) | 25086-89-9 | 25G | ₹2400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P0385 | Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 3:7) (50% in Ethanol) | 25086-89-9 | 500G | ₹6800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P0382 | Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 7:3) (50% in Ethanol) | 25086-89-9 | 25G | ₹2200 | 2022-05-26 | Buy |
Poly(1-vinylpyrrolidone-co-vinyl acetate) Chemical Properties,Uses,Production
Chemical Properties
white powder
Uses
Poly(1-vinylpyrrolidone-co-vinyl acetate)
Production Methods
Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.
General Description
～1:2.4 mole ratio of VP:VA
Pharmaceutical Applications
Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.
Safety Profile
Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx.
Safety
Copovidone is used widely in pharmaceutical formulations and is
generally regarded as nontoxic. However, it is moderately toxic by
ingestion, producing gastric disturbances. It has no irritating or
sensitizing effects on the skin. A study was conducted to look at the
carcinogenicity and chronic toxicity of copovidone (Kollidon VA
64) in Wistar rats and Beagle dogs. The results of these studies
demonstrated the absence of any significant toxicological findings
of high dietary levels of copodivone in rats and dogs, resulting in noobserved-
adverse-effect levels of 2800 mg/kg body-weight/day in
rats and 2500 mg/kg body-weight/day in dogs, the highest doses
tested.
LD50 (rat, oral): >0.63 g/kg
storage
Copovidone is stable and should be stored in a well-closed container in a cool, dry place.
Incompatibilities
Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.
Regulatory Status
Copovidone is included in the FDA Inactive Ingredients Database (oral tablets, oral film-coated tablets, sustained action).
Poly(1-vinylpyrrolidone-co-vinyl acetate) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alcedo Pharmachem Private Limited | +91-9676016431 +91-9177739745 | Telangana, India | 5 | 58 | Inquiry |
| Hubluxe Engineering | 09967552335 | Mumbai, India | 4 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| K P Manish Global Ingredients Private Limited | 91-44-44212345 | Tamil Nadu, India | 36 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Shandong Zhishang New Material Co., Ltd. | +8617653113209 | China | 3050 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12452 | 58 | Inquiry |
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