2-Bromo-4'-hydroxyacetophenone

2-Bromo-4'-hydroxyacetophenone Structure
CAS No.
2491-38-5
Chemical Name:
2-Bromo-4'-hydroxyacetophenone
Synonyms
2-bromo-1-(4-hydroxyphenyl)ethan-1-one;BHAP;BUSAN90;BUSAN1130;Butrol 1130;PTP INHIBITOR I;SHP-1 Inhibitor II;4-HYDROXYPHENACYL BR;4-(Bromoacetyl)phenol;Cyclohexane Impurity 5
CBNumber:
CB9306895
Molecular Formula:
C8H7BrO2
Molecular Weight:
215.04
MOL File:
2491-38-5.mol
Modify Date:
2023/6/8 9:02:43

2-Bromo-4'-hydroxyacetophenone Properties

Melting point 123-126°C
Boiling point 338.7±17.0 °C(Predicted)
Density 1.622±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 7.69±0.15(Predicted)
form White powder
color White to Light Beige
Sensitive Lachrymatory
BRN 1865388
Stability Hygroscopic
CAS DataBase Reference 2491-38-5(CAS DataBase Reference)
EPA Substance Registry System 2-Bromo-4-hydroxyacetophenone (2491-38-5)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Hazard Codes  C,Xn
Risk Statements  22-36
Safety Statements  26
RIDADR  1760
WGK Germany  1
RTECS  AM5982000
Hazard Note  Corrosive/Lachrymatory/Keep Cold
HazardClass  8
PackingGroup  III
HS Code  2914500090
NFPA 704
0
2 0

2-Bromo-4'-hydroxyacetophenone price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) CDS013566 2-bromo-4′-hydroxyacetophenone AldrichCPR 2491-38-5 1G ₹7393.48 2022-06-14 Buy
TCI Chemicals (India) B4115 2-Bromo-4'-hydroxyacetophenone 2491-38-5 5G ₹5400 2022-05-26 Buy
TCI Chemicals (India) B4115 2-Bromo-4'-hydroxyacetophenone 2491-38-5 25G ₹11600 2022-05-26 Buy
Product number Packaging Price Buy
CDS013566 1G ₹7393.48 Buy
B4115 5G ₹5400 Buy
B4115 25G ₹11600 Buy

2-Bromo-4'-hydroxyacetophenone Chemical Properties,Uses,Production

Description

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.

Chemical Properties

Pale Beige Solid

Uses

A covalent inhibitor of protein tyrosine phosphatases (PTPs)

Preparation

Also obtained by reaction of pyridinium hydrobromide perbromide with 4-hydroxyacetophenone in THF at r.t. for 3 h.

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2-Bromo-4'-hydroxyacetophenone Spectrum

PTP INHIBITOR I PROTEIN TYROSINE PHOSPHATASE INHIBITOR I ALPHA-BROMO-4-HYDROXYACETOPHENONE 4-HYDROXYPHENACYL BR 4-HYDROXYPHENACYL BROMIDE 2-BROMO-1-(4-HYDROXY-PHENYL)-ETHANONE 2'-BROMO-4'-HYDROXYACETOPHENONE 2-BROMO-4'-HYDROXYACETOPHENONE 4-Hydroxy α-Bromoacetophenone 4-HYDROXY A-BROMOACETOPHENONE Ethanone, 2-bromo-1-(4-hydroxyphenyl)- A-BROMO-4-HYDROXY ACETOPHENONE 1-(4-hydroxyphenyl)-2-bromoethanone BROMOHYDROXYACETOPHENONE BUSAN1130 BUSAN90 2-Brom-1-(4-hydroxyphenyl)ethan-1-on α-Bromo-4-hydroxyacetophenone 4-Hydroxy-alpha-bromoacetophenone 2-Bromo-4-Hydroxyacetophenone98% Alpha broMine generation of hydroxy acetophenone α-broMo p-hydroxyacetophenone 4-(Bromoacetyl)phenol p-Hydroxy α-Bromoacetophenone 2-Bromo-4'-hydroxyacetophenone, 2-Bromo-1-(4-hydroxyphenyl)ethan-1-one Aipha-BroMo-4-hydroxyacetophenone Butrol 1130 p-Hydroxyphenacyl BroMide 4-Hydroxyphenacyl bromide 97% PTP Inhibitor I - CAS 2491-38-5 - Calbiochem 2-Bromo-4'-hydroxyacetophenone > SHP-1 Inhibitor II 2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) BHAP 2-bromo-1-(4-hydroxyphenyl)ethan-1-one α-Bromo-4-hydroxyacetophenone 2-Bromo-4'-hydroxyacetophenone Cyclohexane Impurity 5 2491-38-5 Aromatics Inhibitors Aromatic Acetophenones & Derivatives (substituted)