SPIROXAMINE
- CAS No.
- 118134-30-8
- Chemical Name:
- SPIROXAMINE
- Synonyms
- IMpulse;KWG 4168;SPIROXAMIN;SPIROXAMINE;Spiro aMine;Spiroxamine 0;Spirocyclovir;Prosper Hoggar;SpiroketalaMine;Spiroxamine [iso]
- CBNumber:
- CB9324635
- Molecular Formula:
- C18H35NO2
- Molecular Weight:
- 297.48
- MOL File:
- 118134-30-8.mol
- Modify Date:
- 2024/7/2 8:55:41
| Melting point | <25 °C |
|---|---|
| Boiling point | bp 120° at 0.067 hPa |
| Density | 0.96±0.1 g/cm3(Predicted) |
| refractive index | nD20 1.4662 |
| Flash point | 147 °C |
| storage temp. | 0-6°C |
| solubility | Chloroform: Slightly Soluble |
| pka | 6.9(at 25℃) |
| form | Liquid |
| color | Colorless to light yellow |
| Stability | Hygroscopic |
| LogP | 4.880 (est) |
| EPA Substance Registry System | Spiroxamine (118134-30-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H317-H361d-H373-H410 | |||||||||
| Precautionary statements | P273-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 20/21/22-38-43-50/53 | |||||||||
| Safety Statements | 36/37/39-46-60-61 | |||||||||
| RIDADR | UN3082 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Toxicity | LD50 in rats (mg/kg): ~595 orally; >1600 dermally; LC50 in rats (mg/m3): ~2772 by inhalation; LC50 (96 hr) in rainbow trout: 18.5 mg/l (Dutzmann) | |||||||||
| NFPA 704 |
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SPIROXAMINE Chemical Properties,Uses,Production
Description
Spiroxamine is a tertiary amine fungicide and an inhibitor of Δ14 reductase/Δ8→Δ7 isomerase. It inhibits the growth of N. parvum, B. dothidea, D. seriata, and L. theobromae isolates from grape vines (EC50s = 0.97-10.28 mg/L). Spiroxamine (0.03-30 μM) reduces network formation in rat cortical cultures. It is also cytotoxic to MDA-kb2 cells (EC20 = 9.29 μM).
Uses
Spiroxamine is a spiroketalamine fungicide for use on cereal crops. Spiroxamine inhibits ergosterol synthesis. Spiroxamine is used as agricultural fungicide.
Definition
ChEBI: The spiroketal resulting from the formal condensation of 4-tert-butylcyclohexanone with 3-[ethyl(propyl)amino]propane-1,2-diol. An inhibitor of ergosterol synthesis, it is a broad spectrum agricultural fungicide used particularly against powde y mildew in the production of cereals, bananas and grapes.
Metabolic pathway
Spiroxamine is metabolized rapidly in plants, soils, water, and animals via similar degradation pathways. The metabolic pathways include hydrolysis and oxidation at several places in the molecule. Side chains are also degraded to various water-soluble conjugates in animals and in plants, and at the end of complete degradation to natural constituents, carbon dioxide is formed in soils as the principal metabolite. The favorable sorption characteristics rule out any possibility of appreciable translocation in soil. In wheat, the total residue is determined in forage, grain, and harvest-ready straw. In the field studies, the residues in the grain are mostly below 0.05 mg kg-1, and only in a few cases up to 0.3 mg kg-1. In the milk of cows ingesting spiroxamine residues with the feed, no residues are found in the least favorable case. In eggs of laying hens, the residue concentrations are below the limit of quantification. There are no residue concentrations detected in the hen fat, meat, and liver.
SPIROXAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| DYUTHI MOTORS PRIVATE LIMITED | 09845269069 | Karnataka, India | 1 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Qingdao Trust Agri Chemical Co.,Ltd | +8613573296305 | China | 270 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | China | 35426 | 58 | Inquiry |