Megestrol acetate
- CAS No.
- 595-33-5
- Chemical Name:
- Megestrol acetate
- Synonyms
- S4;17alpha-acetoxy-6-methylpregna-4,6-diene-3,20-dione;Nia;MGA;bdh1298;sc10363;MEGESTROL ACETATE-D3;6-MethleneProgesterone Acetate;5071;MGA-d3
- CBNumber:
- CB9434253
- Molecular Formula:
- C24H32O4
- Molecular Weight:
- 384.51
- MOL File:
- 595-33-5.mol
- Modify Date:
- 2024/5/29 17:48:59
| Melting point | 214°C |
|---|---|
| alpha | D24 +5° (chloroform) |
| Boiling point | 431.17°C (rough estimate) |
| Density | 1.0474 (rough estimate) |
| refractive index | 11 ° (C=2, CHCl3) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Practically insoluble in water, soluble in acetone, sparingly soluble in alcohol. |
| color | White |
| Merck | 14,5805 |
| BRN | 1917291 |
| InChIKey | RQZAXGRLVPAYTJ-GQFGMJRRSA-N |
| SMILES | C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](OC(C)=O)(C(=O)C)CC3)C=C2C |
| CAS DataBase Reference | 595-33-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Megestrol acetate(595-33-5) |
| EPA Substance Registry System | Megestrol acetate (595-33-5) |
Megestrol acetate price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1583 | Megestrol Acetate Pharmaceutical Secondary Standard; Certified Reference Material | 595-33-5 | 1G | ₹9201.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M0513 | Megestrol acetate analytical standard, for drug analysis | 595-33-5 | 1G | ₹15046.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M0513 | Megestrol acetate analytical standard, for drug analysis | 595-33-5 | 5G | ₹48496 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M1949 | Megestrol Acetate | 595-33-5 | 1G | ₹4700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M1949 | Megestrol Acetate | 595-33-5 | 5G | ₹10400 | 2022-05-26 | Buy |
Megestrol acetate Chemical Properties,Uses,Production
Description
Megestrol Acetate is the acetate salt form of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone with potential anti-estrogenic and antineoplastic activity. It is frequently used in the treatment of patients with metastatic breast cancer. It is generally well tolerated, except that it may cause undesirable weight gain. Subsequently, it was shown that megestrol acetate produced weight gain in a variety of cachectic cancer patients. Significant reduction inserum levels of IL-1a and b,IL-2,IL-6, and TNF-o were observed in cancer patientstreated with megestrol acetate which may bear on the mechanism of improved appetite and body weight gain.It has also been postulated that the effect is, at least in part,mediated by NPY,a potent central appetite stimulant.
Chemical Properties
Crystalline Solid
Uses
Megestrol acetate (Megace), a semi-synthetic progestational steroid, is the most effective known appetite stimulant at present. Previously used in patients with cancer and acquired immunodeficiency syndrome, only a few studies have considered the applicability of this drug in malnourished older persons.
Megestrol acetate is useful if profound anorexia is the main manifestation of cachexia and if expected survival is weeks to months. Megace has been shown to significantly increase appetite, but not survival. In patients with a shorter predicted survival, a brief course of corticosteroids may be useful to stimulate appetite and have positive effects on nausea, pain, and asthenia.
General Description
Megestrol acetate, 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate(Megace), is a progestin used primarily for the palliativemanagement of recurrent, inoperable, or metastatic endometrialor breast carcinoma. Megestrol acetate has also beenindicated for appetite enhancement in patients with AIDS.The biochemical basis for this use of megestrol is unclear.
Clinical Use
Progestin activity is further enhanced when a double bond is introduced between positions 6 and 7, as is found in megestrol acetate. Megestrol is used primarily in the treatment of breast and endometrial carcinomas and in postmenopausal women with advanced hormone-dependent carcinoma.
Safety Profile
Suspected carcinogen with experimental carcinogenic and teratogenic data. Poison by intravenous route. Human reproductive effects bp ingestion and implant routes: effects on ovaries and fallopian tubes, menstrual cycle changes, and female fertility index changes. Mutation data reported. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. An FDA proprietary drug used to treat endometriosis and breast cancer. A steroid.
Metabolism
Less than 10% of an oral dose undergoes metabolism. Several major metabolites appear in the urine (e.g., 2-hydroxy and 6-hydroxymethyl megestrol and their glucuronide conjugates).
Megestrol acetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Besil Chem LLP | +91-7760252666 +91-9880731835 | Bangalore, India | 163 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Ralington Pharma | 91-79-48911722 | Gujarat, India | 312 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| Govind Laboratories P. Ltd. | 91-2717-284368 | Gujarat, India | 18 | 58 | Inquiry |
| Kebee Pharmachemie Pvt., Ltd. | 91-22-28328669 | Maharashtra, India | 65 | 58 | Inquiry |