Megestrol
![Megestrol Structure](CAS/GIF/3562-63-8.gif)
- CAS No.
- 3562-63-8
- Chemical Name:
- Megestrol
- Synonyms
- C07120;Megestro;MEGESTROL;Megestrol USP/EP/BP;megestrol solution,100ppm;Megestrol acetate EP Impurity B;Metesterone acetate EP impurity B;4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE;Megestrol (base and/or unspecified salts);20-dione,17-hydroxy-6-methyl-pregna-6-diene-3
- CBNumber:
- CB5465978
- Molecular Formula:
- C22H30O3
- Molecular Weight:
- 342.47
- MOL File:
- 3562-63-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/19 17:20:51
Melting point | 207-208 °C(Solv: ethyl ether (60-29-7); acetone (67-64-1)) |
---|---|
Boiling point | 500.4±50.0 °C(Predicted) |
Density | 1.15±0.1 g/cm3(Predicted) |
storage temp. | Refrigerator |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 13.00±0.70(Predicted) |
color | White to Off-White |
CAS DataBase Reference | 3562-63-8(CAS DataBase Reference) |
Megestrol Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Megestrol is an orally active progestogen. Megestrol is used in combinations as oral contraceptive and as antineoplastic agent.
Indications
As a representitive of the compounds of the class of progestins, this drug is used for various forms of cancer, in particular cancer of the breast, kidneys, and others.
Definition
ChEBI: A 3-oxo Delta4-steroid that is pregna-4,6-diene-3,20-dione substituted by a hydroxy group at position 17.
World Health Organization (WHO)
Megestrol acetate, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, megestrol acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and megestrol remains available in some countries for contraceptive purposes. In other countries its use is restricted to anticancer treatment. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)
Megestrol Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Biokemix | +91 (40) 6662-6366 | New Delhi, India | 487 | 50 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 15093356674; | China | 29914 | 58 | Inquiry |
BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 12611 | 58 | Inquiry |
Hebei Mojin Biotechnology Co., Ltd | +86-13288715578 +8613288715578 | China | 12464 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
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