CHK2 INHIBITOR II
- CAS No.
- 516480-79-8
- Chemical Name:
- CHK2 INHIBITOR II
- Synonyms
- C 3742;BML-277;CS-1761;BML-277, >98%;Chk2InhibitorⅡ;C 3742 BML-277;BML-277 (C 3742);Chk2 Inhibitor II hydrate;BML-277,CHK2 INHIBITOR II;Chk2 Inhibitor II (BML-277)
- CBNumber:
- CB9503256
- Molecular Formula:
- C20H14ClN3O2
- Molecular Weight:
- 363.8
- MOL File:
- 516480-79-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:13
| Boiling point | 637.1±63.0 °C(Predicted) |
|---|---|
| Density | 1.390±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 18 mg/mL |
| form | solid |
| pka | 10.40±0.10(Predicted) |
| color | tan |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
CHK2 INHIBITOR II price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C3742 | Chk2 Inhibitor II hydrate ≥98% (HPLC) | 516480-79-8 | 5MG | ₹19701.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C3742 | Chk2 Inhibitor II hydrate ≥98% (HPLC) | 516480-79-8 | 25MG | ₹75244.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 220491 | InSolution Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem The InSolution Chk2 Inhibitor II, also referenced under CAS 516480-79-8, controls the biological activity of Chk2. This small molecule/inhibitor is pr | 516480-79-8 | 5MG | ₹20250 | 2022-06-14 | Buy |
CHK2 INHIBITOR II Chemical Properties,Uses,Production
Description
Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.
Uses
Chk2 Inhibitor II is a selective APT-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).
Biochem/physiol Actions
Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).
CHK2 INHIBITOR II Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | China | 3136 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |