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Ginsenoside Rg3

Ginsenoside Rg3 Structure
CAS No.
14197-60-5
Chemical Name:
Ginsenoside Rg3
Synonyms
Rg3;CS-1328;gensenoside RG3;GINSENOSIDE RG3;opyransoyl)oxy)-;(20S)-PROPANAXADIOL;20S-Ginseniside Rg3;GINSENOSIDE Rg3(SH);Ginsenosides rg3(s);Ginsenoside Rg3 (S-)
CBNumber:
CB9713141
Molecular Formula:
C42H72O13
Molecular Weight:
785.03
MOL File:
14197-60-5.mol
MSDS File:
SDS
Modify Date:
2024/4/8 9:57:41
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Ginsenoside Rg3 Properties

Melting point 315-318°C
Boiling point 885.0±65.0 °C(Predicted)
Density 1.30
storage temp. 2-8°C
solubility DMSO: ≥5mg/mL
pka 12.85±0.70(Predicted)
form powder
color white to beige
optical activity [α]/D +10 to +20°, c = 1 in methanol
InChIKey RWXIFXNRCLMQCD-JBVRGBGGSA-N
CAS DataBase Reference 14197-60-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  LY9537300
HS Code  29389090
Toxicity mouse,LD50,intraperitoneal,1250mg/kg (1250mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.
NFPA 704
0
2 0

Ginsenoside Rg3 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0184 Ginsenoside Rg3 ≥98% (HPLC) 14197-60-5 5MG ₹12838.45 2022-06-14 Buy
Sigma-Aldrich(India) SML0184 Ginsenoside Rg3 ≥98% (HPLC) 14197-60-5 25MG ₹52620.33 2022-06-14 Buy
Sigma-Aldrich(India) 64139 Ginsenoside Rg3 analytical standard 14197-60-5 10MG ₹27592.93 2022-06-14 Buy
ottokemi G 1238 Ginsenoside 80% 14197-60-5 5mg ₹5769 2022-05-26 Buy
ottokemi G 1238 Ginsenoside 80% 14197-60-5 25mg ₹23409 2022-05-26 Buy
Product number Packaging Price Buy
SML0184 5MG ₹12838.45 Buy
SML0184 25MG ₹52620.33 Buy
64139 10MG ₹27592.93 Buy
G 1238 5mg ₹5769 Buy
G 1238 25mg ₹23409 Buy

Ginsenoside Rg3 Chemical Properties,Uses,Production

Description

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg3 is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions. Ginsenoside Rg3 induces apoptosis and inhibits angiogenesis in a variety of cancer models. Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.

Uses

Ginsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.

Biochem/physiol Actions

Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation. Ginsenoside Rg3 increases the level of the transcription factor Nrf2 and induces the mRNA levels of multidrug resistance-associated protein (Mrp) 1 and Mrp3. Rg3 modulate neuroinflammation by attenuating the activation of microglia in response to systemic LPS treatment. It activates AMPK in HepG2 cells and reduces the lipid accumulation thereby decreasing the risk of cardiovascular disease due to dyslipidemia.

Ginsenoside Rg3 Preparation Products And Raw materials

Raw materials

Preparation Products

Ginsenoside Rg3 Suppliers

Global( 275)Suppliers
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A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
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Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Otto Chemie Pvt. Ltd. 58
Shaanxi Haibo Biotechnology Co., Ltd 58
career henan chemical co 58
Chengdu Biopurify Phytochemicals Ltd. 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
Zhengzhou Alfa Chemical Co.,Ltd 58

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beta-d-glucopyranoside,(3-beta,12-beta)-12,20-dihydroxydammar-24-en-3-yl2-o-b dammar-24-ene-12-beta,20-diol,3-beta-((2-o-beta-d-glucopyranosyl-beta-d-gluc eta-d-glucopyranosyl- gensenoside RG3 (3β,12β)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside Rg3 GINSENOSIDE RG3 opyransoyl)oxy)- 20(s)-ginsenoside-rg3 (20S)-PROPANAXADIOL Dammar-24-ene-12β,20-diol, 3β-[(2-O-β-D- glucopyranosyl-β-D-glucopyranosyl)oxy]- Ginsenoside 20(s)-Rg3 (20S)-3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]dammarane-24-ene-12β,20-diol 12β,20-Dihydroxy-5α-dammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside 20S-Ginseniside Rg3 Ginsenoside Rg3 (S-) (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside GINSENOSIDE RG3(S-FORM)(P) GINSENOSIDE Rg3(SH) Ginsenoside Rg3 ,98% Monomer Ginsenoside Rg3 (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-DIHYDROXY-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-HYDROXY-17-[(2S)-2-HYDROXY-6-METHYLHEPT-5-EN-2-YL]-4,4,8,10,14-PENTAMETHYL-2,3,5,6,7,9,11,12,13,15,16,17-DODECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-YL]OXY]-6-(HYDROXYMETHYL)OXAN-3-YL]OXY-6-(HYDROXYMETHYL)OXANE-3,4,5-TRIOL Ginsenoside Rg3, 98%, from Panax ginseng C. A. Mey. (11019-45-7) ginsenoside rg3 Ginsenoside Rg3, ≥98%(HPLC) 2-[[4,5-dihydroxy-2-[[12-hydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)-3-oxany CS-1328 Ginsenoside RG3 Natural Plant Extracts HPLC 15% 50% 98% 14197-60-5 Ginsenoside Rg3 (S-Form) β-D-Glucopyranoside, (3β,12β)-12,20-dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl- (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Ginsenosides rg3(s) Ginsenoside S type Rg3 14197-60-5 C42H72O11 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Ginsenoside series Saponins The group of Ginsenosides