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Aliskiren

CAS No.: 173334-57-1

Chemical Name:: Aliskiren

Synonyms: CS-201;SPP 100;Rasilez;Tekturna;CGP60536B;CGP 60536;Aliskiren;Aliskiren Base;Aliskiren (USAN);Aliskiren, >=98%

CBNumber:: CB9966226

Molecular Formula:: C30H53N3O6

Molecular Weight:: 551.76

MOL File:: 173334-57-1.mol

MSDS File:: SDS

Modify Date:: 2024/8/7 19:09:42

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Aliskiren Properties

Melting point	98-99 °C
Boiling point	748.4±60.0 °C(Predicted)
Density	1.067±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO : 100 mg/mL (181.24 mM; Need ultrasonic)
form	Powder
pka	9.49(at 25℃)
color	White to light yellow
CAS DataBase Reference	173334-57-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338

Aliskiren price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	CDS023114	Aliskiren	173334-57-1	10MG	₹18023.63	2022-06-14	Buy

Product number	Packaging	Price	Buy
CDS023114	10MG	₹18023.63	Buy

Aliskiren Chemical Properties,Uses,Production

Description

Aliskiren is a first-in-class antihypertensive drug that acts by direct inhibition of renin. It is indicated for oral administration either as monotherapy or in combination with other antihypertensive agents. Renin catalyzes the cleavage of angiotensin to form angiotensin I, the first and the rate-limiting step of the RAAS. The inhibition of renin by aliskiren results in reduced levels of angiotensin I, angiotensin II, and aldosterone, all of which contribute to the antihypertensive effect. RAAS modulators are among some of the most commonly prescribed antihypertensive agents to date.The most common side effect of aliskiren is diarrhea, particularly with doses higher than 300mg daily. Unlike ACE inhibition, direct inhibition of renin does not increase bradykinin levels. Elevated bradykinin levels are thought to be responsible for the angioderma and cough that occur commonly during treatment with ACE inhibitors. .

Uses

An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive

Definition

ChEBI: A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.

General Description

Aliskiren, (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2-methyl-propyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-propan-2-yl-nonanamide (Tekturna), is the first renin inhibitorintroduced into the U. S. market. It was approved by theFDA in 2007 for the management of hypertension.The trade name for aliskiren in the United Kingdom isRasilez.

Aliskiren Preparation Products And Raw materials

Raw materials

Preparation Products

Aliskiren Suppliers

Global( 185)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Laurus Labs Ltd	+91-4066594333 +91-4039804333	Telangana, India	50	58	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ArkGen Pharma Private Limited	09844366764	Karnataka, India	20	58	Inquiry
Arkgen Farma	09900944880	Karnataka, India	2	58	Inquiry
Chiral Biosciences Limited	09441920381	Mallapur, India	41	58	Inquiry
Splendid Lab	09920994403	Pune, India	5	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	China	12452	58	Inquiry
Hebei Guanlang Biotechnology Co,.LTD	+86-19930503253; +8619930503252	China	5831	58	Inquiry

Supplier	Advantage
Laurus Labs Ltd	58
Manus Aktteva	34
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
ArkGen Pharma Private Limited	58
Arkgen Farma	58
Chiral Biosciences Limited	58
Splendid Lab	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Guanlang Biotechnology Co,.LTD	58

Aliskiren Spectrum

Aliskiren(173334-57-1)¹HNMR

173334-57-1(Aliskiren)Related Search:

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Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- Aliskiren hemifumarate Aliskiren inter-8

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Aliskiren (aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeneoctanamide CGP 60536 CGP60536B Rasilez SPP 100 Tekturna (aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,z-bis(1-methylethyl)benzeneoctanamide (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide ALISKIREN FREE BASE (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-Methoxybenzyl)-5-aMino-N-(2-carbaMoyl-2-Methylpropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide Aliskiren (CGP 60536) Aliskiren (USAN) (2S,4S,5S,7S)-7-(4-Methoxy-3-(3-Methoxypropoxy)benzyl)-5-aMino-N-(3-aMino-2,2-diMethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide Aliskiren Base 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate Aliskiren, >=98% 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypr CGP 60536;CGP60536B;SPP 100 CS-201 CGP-60536; CGP60536; TEKTURNA;SPP 100 Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)- Aliskiren USP/EP/BP (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide Aliskiren 99% CAS NO.173334-57-1 173334-57-1 C30H53N3O6HCl C30H53N3O6 C34H57N3O10 C30H53N3O6C4H4O4 API Amines Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Chemical Amines Aliskiren intermediates