Aliskiren
![Aliskiren Structure](CAS/GIF/173334-57-1.gif)
- CAS No.
- 173334-57-1
- Chemical Name:
- Aliskiren
- Synonyms
- CS-201;SPP 100;Rasilez;Tekturna;CGP60536B;CGP 60536;Aliskiren;Aliskiren Base;Aliskiren (USAN);Aliskiren, >=98%
- CBNumber:
- CB9966226
- Molecular Formula:
- C30H53N3O6
- Molecular Weight:
- 551.76
- MOL File:
- 173334-57-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/7 19:09:42
Melting point | 98-99 °C |
---|---|
Boiling point | 748.4±60.0 °C(Predicted) |
Density | 1.067±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO : 100 mg/mL (181.24 mM; Need ultrasonic) |
form | Powder |
pka | 9.49(at 25℃) |
color | White to light yellow |
CAS DataBase Reference | 173334-57-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
Aliskiren Chemical Properties,Uses,Production
Description
Aliskiren is a first-in-class antihypertensive drug that acts by direct inhibition of renin. It is indicated for oral administration either as monotherapy or in combination with other antihypertensive agents. Renin catalyzes the cleavage of angiotensin to form angiotensin I, the first and the rate-limiting step of the RAAS. The inhibition of renin by aliskiren results in reduced levels of angiotensin I, angiotensin II, and aldosterone, all of which contribute to the antihypertensive effect. RAAS modulators are among some of the most commonly prescribed antihypertensive agents to date.The most common side effect of aliskiren is diarrhea, particularly with doses higher than 300mg daily. Unlike ACE inhibition, direct inhibition of renin does not increase bradykinin levels. Elevated bradykinin levels are thought to be responsible for the angioderma and cough that occur commonly during treatment with ACE inhibitors. .
Uses
An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive
Definition
ChEBI: A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.
General Description
Aliskiren, (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2-methyl-propyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-propan-2-yl-nonanamide (Tekturna), is the first renin inhibitorintroduced into the U. S. market. It was approved by theFDA in 2007 for the management of hypertension.The trade name for aliskiren in the United Kingdom isRasilez.
Aliskiren Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Laurus Labs Ltd | +91-4066594333 +91-4039804333 | Telangana, India | 50 | 58 | Inquiry |
Manus Aktteva | +91 (79) 6512-3395 | New Delhi, India | 581 | 34 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
ArkGen Pharma Private Limited | 09844366764 | Karnataka, India | 20 | 58 | Inquiry |
Arkgen Farma | 09900944880 | Karnataka, India | 2 | 58 | Inquiry |
Chiral Biosciences Limited | 09441920381 | Mallapur, India | 41 | 58 | Inquiry |
Splendid Lab | 09920994403 | Pune, India | 5 | 58 | Inquiry |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12452 | 58 | Inquiry |
Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5831 | 58 | Inquiry |
Supplier | Advantage |
---|---|
Laurus Labs Ltd | 58 |
Manus Aktteva | 34 |
CLEARSYNTH LABS LTD. | 58 |
A.J Chemicals | 58 |
ArkGen Pharma Private Limited | 58 |
Arkgen Farma | 58 |
Chiral Biosciences Limited | 58 |
Splendid Lab | 58 |
Hebei Mojin Biotechnology Co., Ltd | 58 |
Hebei Guanlang Biotechnology Co,.LTD | 58 |
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