アデノシン 5′-三リン酸, 過ヨウ素酸 酸化 ナトリウム塩 化学特性,用途語,生産方法
使用
Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:
- as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
- as a nonspecific agonist to assess the activity of P2×7-R by the mobilization of Ca2+
- to evaluate the physiological significance of elevated intracellular ATP levels
- increased?P2rx7?expression for osteoclastogenesis in?Flcn-deficient cells
一般的な説明
A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X
7 purinergic receptors in J774 mouse macrophages. Does not affect P2
γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X
7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca
2+ influx in lymphocytes (?100 μM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
Biochem/physiol Actions
Reversible: no
アデノシン 5′-三リン酸, 過ヨウ素酸 酸化 ナトリウム塩 上流と下流の製品情報
原材料
準備製品