ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT 속성
저장 조건
-20°C
물리적 상태
백색분말
색상
White to off-white
안전
WGK 독일
3
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT C화학적 특성, 용도, 생산
용도
Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:
as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
as a nonspecific agonist to assess the activity of P2×7-R by the mobilization of Ca2+
to evaluate the physiological significance of elevated intracellular ATP levels
increased?P2rx7?expression for osteoclastogenesis in?Flcn-deficient cells
일반 설명
A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (?100 μM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
Biochem/physiol Actions
Reversible: no
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT 준비 용품 및 원자재
원자재
준비 용품
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT 공급 업체
