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2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-

化学構造式
1010096-65-7
CAS番号.
1010096-65-7
化学名:
别名:
英語名:
2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-
英語别名:
AM6701;LY2183240 2’LY2183240 2’-isomer;LY2183240 2’-isomer Exclusive;LY2183240 2'-isomer Exclusive;5-([1,1-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide;2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-
CBNumber:
CB32667875
化学式:
C17H17N5O
分子量:
307.35
MOL File:
1010096-65-7.mol

2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl- 物理性質

沸点 :
506.1±53.0 °C(Predicted)
比重(密度) :
1.21±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.1 mg/ml
外見 :
A crystalline solid
酸解離定数(Pka):
-1.73±0.12(Predicted)
色:
Light yellow to yellow

安全性情報

2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl- 価格 もっと(3)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CAY14523
LY2183240 2'-isomer 		1010096-65-7 1mg ￥26000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01CAY14523
LY2183240 2'-isomer 		1010096-65-7 5mg ￥70600 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01CAY14523
LY2183240 2'-isomer 		1010096-65-7 10mg ￥126300 2024-03-01 購入

2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl- 化学特性,用途語,生産方法

説明

LY2183240 is a potent, competitive small molecule inhibitor of anandamide uptake (IC50 = 270 pM; Ki = 540 pM) and hydrolysis. It has been shown to increase anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-dependent efficacy (3-30 mg/kg) in several rodent models of persistent pain. LY2183240 2’-isomer is a less potent, 2,5-regioisomer of LY2183240 that inhibits anandamide hydrolysis and uptake with IC50 values of 33 and 998 nM, respectively.

使用

5-([1,1''-Biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide is an inhibitor of human monoacylglycerol lipase (hMGL).

2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl- 上流と下流の製品情報

原材料

準備製品

2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl- 生産企業

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  • 1010096-65-7
  • 2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-
  • LY2183240 2’-isomer
  • LY2183240 2'-isomer Exclusive
  • 5-([1,1-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide
  • LY2183240 2&rsquo
  • AM6701
  • LY2183240 2’-isomer Exclusive
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