12,13-エポキシトリコテカ-9-エン-3α,4β,8α,15-テトラオール4,15-ジアセタート8-(3-メチルブタノアート) 化学特性,用途語,生産方法
外観
白色〜ほとんど白色, 結晶性粉末〜粉末
溶解性
メタノールに溶ける。
使用上の注意
アルゴン封入
説明
T-2 toxin is a trichothecene mycotoxin that has been found in
Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC
50 = 19.47), primary pig alveolar macrophages (PAMs).
In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD
50s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.
化学的特性
White powder
使用
T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration.
一般的な説明
T-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains.
安全性プロファイル
Poison by ingestion,
intramuscular, subcutaneous, intraperitoneal,
intracerebral, and intravenous routes.
Moderately toxic by inhalation.
Experimental teratogenic and reproductive
effects. A skin irritant. Questionable
carcinogen with experimental neoplastigenic
data. Mutation data reported. When heated
to decomposition it emits acrid smoke and
irritating fumes.
12,13-エポキシトリコテカ-9-エン-3α,4β,8α,15-テトラオール4,15-ジアセタート8-(3-メチルブタノアート) 上流と下流の製品情報
原材料
準備製品