ロペラミド
|
|
|
- CAS番号.
- 53179-11-6
- 化学名:
- ロペラミド
- 别名:
- 4-[4-ヒドロキシ-4-(4-クロロフェニル)-1-ピペリジニル]-2,2-ジフェニル-N,N-ジメチルブタンアミド;4-(4-クロロフェニル)-4-ヒドロキシ-N,N-ジメチル-α,α-ジフェニル-1-ピペリジンブチルアミド;4-(4-クロロフェニル)-4-ヒドロキシ-N,N-ジメチル-α,α-ジフェニル-1-ピペリジンブタンアミド;4-[4-(p-クロロフェニル)-4-ヒドロキシピペリジノ]-2,2-ジフェニル-N,N-ジメチルブチルアミド;ロペラミド
- 英語名:
- Loperamide
- 英語别名:
- C07080;Tebloc;utanamide;LOPERAMIDE;Loperamide Monomer;Loperamide USP/EP/BP;4-(4-chlorophenyl)-n,n-dimethyl-alpha;4-(4-chlorophenyl)-n,n-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidineb;4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-,-diphenyl-1-p-piperidinebutanamide;4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide
- CBNumber:
- CB7402928
- 化学式:
- C29H33ClN2O2
- 分子量:
- 477.04
- MOL File:
- 53179-11-6.mol
|
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| 注意書き |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時に、飲食または喫煙をしないこ と。 |
| P301+P310 |
飲み込んだ場合：直ちに医師に連絡すること。 |
| P321 |
特別な処置が必要である（このラベルの．．． を見よ）。 |
| P330 |
口をすすぐこと。 |
| P405 |
施錠して保管すること。 |
| P501 |
内容物/容器を．．．に廃棄すること。 |
|
ロペラミド 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
ロペラミド 化学特性,用途語,生産方法
効能
止瀉薬, 蠕動抑制薬, オピオイド受容体作動薬
使用
Loperamide is presently used more often as an antidiarrheal drug than as an analgesic, and
it is also included in the list of over-the-counter drugs because of its insignificant action on
the CNS. It reduces intestinal smooth muscle tone and motility as a result of binding to
intestinal opiate receptors. It is used for symptomatic treatment of severe and chronic diarrhea of various origins. The most popular synonym for loperamide is imodium.
定義
ChEBI: A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
世界保健機関（WHO）
Loperamide, an inhibitor of intestinal peristalsis, was introduced
in 1975 for the treatment of acute and chronic diarrhoea. In many countries its use
was discouraged in young children. In late 1989, treatment of infants in Pakistan
was associated with 19 cases of paralytic ileus, 6 of which have been fatal. This
has subsequently led the major manufacturer to withdraw all drop formulations of the drug worldwide as well as the lower dose syrup forms from countries where
there is a programme for the control of diarrhoeal diseases. The WHO Control of
Diarrhoeal Diseases Programme recommends that loperamide should not be used
in children below five year of age.
(Reference: (LJJ) Letter to WHO from Johnson & Johnson, , , 21 June 1990)
一般的な説明
Loperamide (Imodium) is a 4-phenylypiperidine with amethadone-like structure attached to the piperidine nitrogen. It acts as an antidiarrheal by directly binding tothe opiate receptors in the gut wall. Loperamide inhibitsacetylcholine and prostaglandin release, decreasing peristalsisand fluid secretion thus increasing the GI transit time andreducing the volume of fecal matter.Loperamide is sufficiently lipophilic to cross the blood-brain barrier, yet itdisplays no CNS-opioid effects. The reason for this is that itis actively pumped out of the brain via the P-glycoproteinpump (MDR1). Knockout mice with the P-glycoproteinpump genetically removed were given radiolabeled loperamideand sacrificed 4 hours later. The [
3H]loperamideconcentrations were measured and compared with wild-typemice. A 13.5-fold increase in loperamide concentration wasfound in the brain of the knockouts. In addition, the micelacking the P-glycoprotein pump displayed pronouncedsigns of central opiate agonism. Loperamide is availableas 2-mg capsules for treatment of acute and chronic diarrhea.Recommended dosage is 4 mg initially, with 2 mgafter each loose stool for a maximum of 16 mg/d.
ロペラミド 上流と下流の製品情報
原材料
準備製品
ロペラミド 生産企業
Global( 69)Suppliers
53179-11-6(ロペラミド)キーワード:
- 53179-11-6
- 4-[4-Chlorophenyl]-4-hydroxy-N, N-dimethyl-α,α-diphenyl-1-piperidinebutanamide
- 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide
- 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-,-diphenyl-1-p-piperidinebutanamide
- LOPERAMIDE
- 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-di(phenyl)butanamide
- 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N DIMETHYL-A,A DIPHENYL-1-PEIPERIDINE BUTANAMIDEHCL
- 4-(4-chlorophenyl)-n,n-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidineb
- 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide
- 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-2,2-diphenyl-N,N-dimethylbutyramide
- 4-[4-Hydroxy-4-(4-chlorophenyl)-1-piperidinyl]-2,2-diphenyl-N,N-dimethylbutanamide
- C07080
- Tebloc
- utanamide
- 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-N,N-dimethyl-2,2-diphenylbutanamide
- 4-(4-chlorophenyl)-n,n-dimethyl-alpha
- 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-
- Loperamide USP/EP/BP
- LoperamideQ: What is
Loperamide Q: What is the CAS Number of
Loperamide Q: What is the storage condition of
Loperamide
- 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutanamide
- Loperamide
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl- 2,2-diphenylbutanamide
- Loperamide Monomer
- 4-[4-ヒドロキシ-4-(4-クロロフェニル)-1-ピペリジニル]-2,2-ジフェニル-N,N-ジメチルブタンアミド
- 4-(4-クロロフェニル)-4-ヒドロキシ-N,N-ジメチル-α,α-ジフェニル-1-ピペリジンブチルアミド
- 4-(4-クロロフェニル)-4-ヒドロキシ-N,N-ジメチル-α,α-ジフェニル-1-ピペリジンブタンアミド
- 4-[4-(p-クロロフェニル)-4-ヒドロキシピペリジノ]-2,2-ジフェニル-N,N-ジメチルブチルアミド
- ロペラミド
- 制瀉薬