ジメチルカルバモイルクロリド 化学特性,用途語,生産方法
外観
無色~うすい黄色、液体
用途
有機合成原料。
用途
有機合成中間体
化学的特性
Clear colorless liquid
使用
Dimethylcarbamoyl chloride has been used primarily as a chemical intermediate in the production of dyes, pharmaceuticals, pesticides, and rocket fuel (IARC 1999, HSDB 2009).
一般的な説明
A colorless to yellow liquid with a pungent odor. Burns to skin, eyes and mucous membranes. A lachrymator. Used to make dyes and pharmaceuticals.
空気と水の反応
Reacts with water or moisture in the air to form hydrochloric acid and dimethylcarbamic acid.
反応プロフィール
Dimethylcarbamoyl chloride is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. Gives toxic fumes of NOx and HCl when burned [USCG, 1999].
健康ハザード
Material is extremely destructive to the mucous membranes, upper respiratory tract, eyes, and skin. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
火災危険
Special Hazards of Combustion Products: Toxic fumes of NO x and HCl
毒性学
The LD50
is 1170 mg/kg upon oral administration to rats
and 350 mg/kg upon intraperitoneal administration to mice. The compound is irritating to
the skin and eyes. All the test animals survived
an 8-min inhalation test in an atmosphere saturated with vapors of the substance at 20℃.
Longer exposure times led to death. No sensitization was observed in animal experiments.
安全性プロファイル
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Poison
by intraperitoneal route. Moderately toxic by
inhalation and ingestion. Human mutation
data reported. Can cause skin and paplllary
tumors by skin contact, and squamous cell
carcinoma by inhalation. Will react with
water or steam to produce toxic and
corrosive fumes. A powerful lachrymator.
When heated to decomposition it emits very
toxic fumes of Cland NOx. See also
CHLORIDES.
発がん性
Dimethylcarbamoyl chloride is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
純化方法
It must be distilled under high vacuum to avoid decomposition. [Beilstein 4 IV 224.]
ジメチルカルバモイルクロリド 上流と下流の製品情報
原材料
準備製品
1,4,5,8-ナフタレンテトラカルボン酸
4-AMINOMETHYL-PYRIDINE-2-CARBOXYLIC ACID
4-(TRIMETHYL-UREIDO)-BENZENESULFONYL CHLORIDE
3-(TERT-BUTOXYCARBONYLAMINO-METHYL)-PYRIDINE-2-CARBOXYLIC ACID
N'-(4-イソプロピルフェニル)-N,N-ジメチル尿素
4-メチルピリジン-2-カルボン酸
ジメチルカルバミド酸3-ピリジニル
ジチオりん酸S-(4,6-ジアミノ-1,3,5-トリアジン-2-イル)メチルO,O-ジメチル
1,1'-アゾビス(N,N-ジメチルホルムアミド)
ネオスチグミン ブロミド
3-AMINOMETHYL-PYRIDINE-2-CARBOXYLIC ACID
4-[(TERT-BUTOXYCARBONYLAMINO)METHYL]-2-CYANOPYRIDINE
2,2'-DINAPHTHYL KETONE
ピペラジン-1-カルボン酸ジメチルアミド
2-CYANOPYRIDINE-4-CARBOXALDEHYDE
ジメチルカルバミド酸エチル
4-[(tert-ブトキシカルボニルアミノ)メチル]-2-ピリジンカルボン酸
3-AMINOPHENYL N,N-DIMETHYLCARBAMATE, 97
N,N-ジメチル-2-ピペラジン-1-イル-アセトアミド
4-(HYDROXYMETHYL)PICOLINITRILE
2-シアノ-4-メチルピリジン
ETHYL 2-CYANOPYRIDINE-4-CARBOXYLATE
4-クロロ-2-シアノピリジン
ジメチルカルバミド酸m-(ジメチルアミノ)フェニル