GLP-1

GLP-1 속성

GLP-1 C화학적 특성, 용도, 생산

역사

GLP-1 was first identified in the early 1980s, following the cloning of the proglucagon gene. The biological activity of GLP-1 was investigated initially by using the N-terminal extended forms of GLP-1(1–37 and 1–36 amide). However, these forms were devoid of biological activity. In the late 1980s, bioactive GLP-1 peptides were purified from gut extracts and were identified to be GLP1(7–37) and GLP-1(7–36)-amide. In the current literature, the unqualified designation of GLP-1 corresponds to the truncated peptides.

용도

Glucagon-Like Peptide I (GLP1) has been used as an antigen in excess amounts for the incubation of primary antibodies, post-immunocytochemistry with positive results of paraffin-embedded pancreatic tissues of Rana temporaria.

일반 설명

Glucagon-Like Peptide I (GLP1) is an incretin hormone, which functions as ligand for GLP1 receptors (GLP1R). These receptors are expressed in renal and cardiovascular system, such as smooth muscle and endothelial cells.

Biochem/physiol Actions

Glucagon-Like Peptide I (GLP1) controls the metabolism of glucose, by inducing the secretion of insulin and suppressing that of glucagon. Studies in Indonesian population show that reduced levels of this protein are linked with increased susceptibility to type 2 diabetes mellitus. Plasma levels of this hormone also show significant association with systolic and diastolic blood pressure levels.

부작용

Common side effects of GLP-1 include: loss of appetite, nausea, vomiting, diarrhoea. Other side effects may include: dizziness, mild tachycardia or increased heart rate, infection, headache, and indigestion. Temporary mild itching and redness of the skin at the injection site may also occur. Serious and rare side effects include: pancreatitis, medullary thyroid cancer, acute (sudden) kidney injury, worsening of diabetes-related retinopathy, and severe allergic reactions. And GLP-1 agonists are recommended during pregnancy because they can cause abnormal foetal development. Seek medical attention if any serious adverse reactions occur.

GLP-1 준비 용품 및 원자재

원자재

준비 용품

GLP-1 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Strong peptide cross-border e-commerce Co. LTD	+undefined13930052870	qt01@qiangtaipharm.com	China	84	58
Qingdao Xinli Technology Development Co., Ltd.	+8616632313095	xinlikeji01@qdxlchem.com	China	130	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	973	58
Shanghai Affida new material science and technology center	+undefined15081010295	admin@oudaxin.com	China	114	58
Sigma Audley	+86-18336680971 +86-18126314766	nova@sh-teruiop.com	China	496	58
Hebei Kangcang new material Technology Co., LTD	+8615713292910	Nancy@kangcang.com.cn	China	341	58
CONTIDE BIOTECH CO.,LTD	+852-53358525	xena@healthtide-api.com	China	584	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10260	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58

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