β-브로모에틸벤젠
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β-브로모에틸벤젠 속성
- 녹는점
- -56 °C
- 끓는 점
- 220-221 °C(lit.)
- 밀도
- 1.355 g/mL at 25 °C(lit.)
- 굴절률
- n
20/D 1.556(lit.)
- 인화점
- 193 °F
- 저장 조건
- 2-8°C
- 용해도
- 0.039g/L
- 물리적 상태
- 액체
- 색상
- 무색~담황색 투명
- 수용성
- 불용성
- BRN
- 507487
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- WMPPDTMATNBGJN-UHFFFAOYSA-N
- CAS 데이터베이스
- 103-63-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36-36/37/38 | ||
안전지침서 | 26-37/39-39 | ||
유엔번호(UN No.) | UN 1993 / PGIII | ||
WGK 독일 | 3 | ||
RTECS 번호 | CY9032000 | ||
TSCA | Yes | ||
HS 번호 | 29036990 | ||
유해 물질 데이터 | 103-63-9(Hazardous Substances Data) | ||
기존화학 물질 | KE-03671 |
β-브로모에틸벤젠 C화학적 특성, 용도, 생산
개요
Phenethylbromide is an analytical reference material that is structurally categorized as an organobromide. It is used in the synthesis of a variety of compounds, including fentanyl. Phenethylbromide is combined with 4-piperidinone to produce N-phenethyl-4-piperidone, which, as a precursor in the synthesis of fentanyl, is scheduled as a List I chemical in the United States. Phenethylbromide may be found as in impurity in samples of fentanyl produced using this pathway.화학적 성질
colourless to yellow liquid. It is miscible with ether and benzene, but insoluble in water.용도
(2-Bromoethyl)benzene is used in the preparation of phenelzine by reacting with hydrazine. It is also used as a starting material to prepare various beta-phenethyl derivatives, active pharmaceutical ingredients, and fragrances. It finds application as a flame retardant.용도
(2-Bromoethyl)benzene is an important starting material for the production of various b-phenethyl derivatives, pharmaceuticals, fragrances, and other fine chemicals.제조 방법
(2-Bromoethyl)benzene is synthesized by the reaction of phenethyl alcohol with hydrogen bromide.Reaction: The phenethyl alcohol was heated to 110°C, hydrogen bromide was slowly introduced, and the reaction was refluxed. The reaction was completed, cooled, washed with water, 10% sodium carbonate solution, and water in turn. After drying with anhydrous potassium carbonate, fractional distillation under reduced pressure was carried out to collect fractions at 97-99°C (2.0 kPa) with a yield of over 90%.
Safety
Store at 2-8° C in a tightly closed container in a dry, well-ventilated place. Containers that are opened must be carefully resealed and kept upright to prevent leakage. (2-Bromoethyl)benzene is incompatible with strong oxidizing agents. This chemical is harmful if swallowed and causes severe eye irritation.Purification Methods
Wash the bromide with conc H2SO4, water, aqueous 10% Na2CO3 and water again, then dry it with CaCl2 and fractionally distil it just before use. [Beilstein 5 IV 907.]참고 문헌
1. Shukla, P.; Sharma, A.; Pallavi, B.; Cheng, C. H. Nickel-catalyzed reductive Heck type coupling of saturated alkyl halides with acrylates and oxabenzonorbornadiene. Tetrahedron 2015, 71 (15), 2260-2266. DOI:10.1016/J.TET.2015.02.0672. Huang, Y. B.; Yan, L.; Chen, M. Y.; Guo, Q. X.; Fu, Y. Selective hydrogenolysis of phenols and phenyl ethers to arenes through direct C-O cleavage over ruthenium-tungsten bifunctional catalysts. Green Chem. 2015, 17 (5), 3010-3017. DOI:10.1039/C5GC00326A
3. Justice, D.E.A.D.o. Control of a chemical precursor used in the illicit manufacture of fentanyl as a List I chemical. Final rule. Federal Register 73(144), 43355-43357 (2008). PMID: 18949877
β-브로모에틸벤젠 준비 용품 및 원자재
원자재
준비 용품
1-Phenyl-1,2-ethanediol
1-(2-PHENYLETHYL)PIPERAZINE
4-Vinylbenzyl chloride
N-METHYLPHENETHYLAMINE
카르펜타닐
Benzene, [dimethyl(2-phenylethyl)silyl]-
5-페닐-N-발레릭산메틸에스테르
디에틸2-아세트아미도-2-페네틸-프로판디오에이트
2-페닐에틸-1-붕소산피나콜에스테르
1-(페닐)2-니트로에탄
2-페닐에틸페닐에테르
4-(2-브로모에틸)벤조산
센티폴
1,4-DIPHENYLBUTANE
1-브로모-4-페닐부탄
2-PHENYLETHYL PROPIONATE
1,2-Ethanediyl, 1-phenyl- (9CI)
β-브로모에틸벤젠 공급 업체
글로벌( 564)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 |
info@longyupharma.com | China | 2534 | 58 |
Siyang Liaoning Biochemical Products Co. Ltd | +86-15221114306; +8615221114306 |
2594582574@qq.com | China | 574 | 58 |
Shijiazhuang Gantuo Biotechnology Co., Ltd | +8613373514458 |
gantuo02@cngantuo.com | China | 218 | 58 |
LY Global chemicals co.,ltd . | +8618939937369 |
info@lychems.cn | China | 969 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Shijiazhuang Jianxin Biotechnology Co., LTD | +undefined-86-1906231316-9 +undefined86-19062313169 |
liyingjian1997@gmail.com | China | 709 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 |
sales8@hbganmiao.com | China | 300 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 |
Ethan@dornechem.com | China | 3128 | 58 |
Hubei Aumei New Material Co., Ltd. | +86-027-87366298 +8615927270571 |
tianyi@skbiology.cn | China | 294 | 58 |
Hebei Dangtong Import and export Co LTD | +86-13910575315 +86-13910575315 |
admin@hbdangtong.com | China | 1005 | 58 |