펜에틸알코올
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펜에틸알코올 속성
- 녹는점
- -27 °C (lit.)
- 끓는 점
- 219-221 °C/750 mmHg (lit.)
- 밀도
- 1.020 g/mL at 20 °C (lit.)
- 증기 밀도
- 4.21 (vs air)
- 증기압
- 1 mm Hg ( 58 °C)
- 굴절률
- n
20/D 1.5317(lit.)
- 인화점
- 216 °F
- 저장 조건
- Store below +30°C.
- 용해도
- 클로로포름과 혼합 가능.
- 산도 계수 (pKa)
- 15.17±0.10(Predicted)
- 물리적 상태
- 액체
- 색상
- 무색의
- 냄새
- 장미 꽃향기
- 수소이온지수(pH)
- 6-7 (20g/l, H2O, 20℃)
- 폭발한계
- 1.4-11.9%(V)
- ?? ??
- 꽃향기
- 수용성
- 20g/L(20℃)
- Merck
- 14,7224
- JECFA Number
- 987
- BRN
- 1905732
- Dielectric constant
- 13.0(20℃)
- 안정성
- 안정적인. 피해야 할 물질에는 강산과 강산화제가 포함됩니다. 타기 쉬운.
- InChIKey
- WRMNZCZEMHIOCP-UHFFFAOYSA-N
- LogP
- 1.50
- CAS 데이터베이스
- 60-12-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 21/22-36/38-36-22 | ||
안전지침서 | 26-28-36/37-36/37/39 | ||
유엔번호(UN No.) | 2810 | ||
WGK 독일 | 1 | ||
RTECS 번호 | SG7175000 | ||
자연 발화 온도 | 410 °C | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | III | ||
HS 번호 | 29062990 | ||
유해 물질 데이터 | 60-12-8(Hazardous Substances Data) | ||
독성 | LD50 orally in rats: 1790 mg/kg (Jenner) | ||
기존화학 물질 | KE-28354 |
펜에틸알코올 C화학적 특성, 용도, 생산
화학적 성질
Phenethyl alcohol is the main component of rose oils obtained from rose blossoms. It occurs in smaller quantities in neroli oil, ylang-ylang oil, carnation oil, and geranium oils. Since the alcohol is rather soluble in water, losses occur when essential oils are produced by steam distillation.Phenylethyl alcohol is a colorless liquid with a mild rose odor. It can be dehydrogenated catalytically to phenylacetaldehyde and oxidized to phenylacetic acid (e.g.,with chromic acid). Its fatty acid esterswith lowermolecularmass, as well as some alkyl ethers, are valuable fragrance and flavor substances.
출처
Reported found (as is or esterified) in several natural products: rose concentrate, rose absolute (60% or more) and rose distillation waters; also found in the essential oils of neroli, ylang-ylang, narcissus, hyacinth, lily, tea leaves, Michelia champaca, Pandamus odoratissimus, Congo and Réunion geranium, tobacco and other oils. It has been identified in wines. It has also been reported found in over 200 foods and beverages including apple, apricot, orange juice, orange peel, many berries, bilberry, cherry, grapefruit, peach, raisin, blackberry, guava, grapes, melon, papaya, asparagus, cabbage, leek, potato, rutabaga, tomato, Mentha oils, cinnamon, ginger, breads, butter, saffron, mustard, mango, many cheeses, butter, milk, cooked chicken, cognac, hop oil, beer, rum, whiskies, cider, sherry, cocoa, coffee, tea, nuts, oats, honey, soybean, coconut meat, avocado, olive, passion fruit, plum, beans, mushroom, starfruit, mango, tamarind, fruit brandies, fig, gin, rice, quince, radish, litchi, sukiyaki, calamus, licorice, buckwheat, watercress, elderberry fruit, kiwifruit, loquat, Tahiti and Bourbon vanilla, mountain papaya, endive, lemon balm, clary sage, shrimps, crab, Chinese quince, lamb’s lettuce, truffle and maté.용도
phenethyl alcohol is used to mask odor and also as a preservative.제조 방법
From toluene, benzene or styrene.생산 방법
Phenylethyl alcohol is prepared by reduction of ethyl phenylacetate with sodium in absolute alcohol; by hydrogenation of phenylacetaldehyde in the presence of a nickel catalyst; or by addition of ethylene oxide or ethylene chlorohydrin to phenylmagnesium bromide, followed by hydrolysis. Phenylethyl alcohol also occurs naturally in a number of essential oils, especially rose oil.일반 설명
Phenylethyl alcohol, is a primary aromatic alcohol of high boiling point, having a characteristic rose-like odor. It presents organoleptic properties and impacts the quality of the wine, distilled beverages, and fermented foods. It shows its presence in fresh beer and is responsible for the rose-like odor of well-ripened cheese. It is commercially and industrially an important flavor and is a component of a variety of foodstuffs such as ice cream, gelatin, candy, pudding, chewing gum, and non-alcoholic beverages. It is formed by yeasts during fermentation of alcohols either by decomposition of L-phenylalanine or metabolism of sugar substrates.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
건강위험
Phenylethanol is an irritant of the eyes and a teratogen in rats.Pharmaceutical Applications
Phenylethyl alcohol is used as an antimicrobial preservative in nasal, ophthalmic, and otic formulations at 0.25–0.5% v/v concentration; it is generally used in combination with other preservatives.Phenylethyl alcohol has also been used on its own as an antimicrobial preservative at concentrations up to 1% v/v in topical preparations. At this concentration, mycoplasmas are inactivated within 20 minutes, although enveloped viruses are resistant.Phenylethyl alcohol is also used in flavors and as a perfumery component, especially in rose perfumes.Safety Profile
Moderately toxic by ingestion and skin contact. A skin and eye irritant. Experimental teratogenic effects. Other experimental reproductive effects. Causes severe central nervous system injury to experimental animals. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidzing materials. To fight fEe, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumesSafety
Phenylethyl alcohol is generally regarded as a nontoxic and nonirritant material. However, at the concentration used to preserve eye-drops (about 0.5% v/v) or above, eye irritation may occur.LD50 (rabbit, skin): 0.79 g/kg
LD50 (rat, oral): 1.79 g/kg
Carcinogenicity
Phenylethanol was not mutagenic in bacterial assays, nor did it increase the number of sister chromatid exchanges in human lymphocytes.신진 대사
Phenylethyl alcohol is oxidized almost entirely to the corresponding acid (Williams. 1959).저장
Phenylethyl alcohol is stable in bulk, but is volatile and sensitive to light and oxidizing agents. It is reasonably stable in both acidic and alkaline solutions. Aqueous solutions may be sterilized by autoclaving. If stored in low-density polyethylene containers, phenylethyl alcohol may be absorbed by the containers. Losses to polypropylene containers have been reported to be insignificant over 12 weeks at 30°C. Sorption to rubber closures is generally small.The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.
Purification Methods
Purify the ethanol by shaking it with a solution of ferrous sulfate, and the alcohol layer is washed with distilled water and fractionally distilled. [Beilstein 6 IV 3067.]비 호환성
Incompatible with oxidizing agents and protein, e.g. serum. Phenylethyl alcohol is partially inactivated by polysorbates, although this is not as great as the reduction in antimicrobial activity that occurs with parabens and polysorbates.Regulatory Status
Included in the FDA Inactive Ingredients Database (nasal, ophthalmic, and otic preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.펜에틸알코올 준비 용품 및 원자재
원자재
발연황산
염화벤질
질소
Grignard reagent
에틸렌옥사이드
Motor benzol
브롬화 나트륨
스티렌 모노머
Air blower
스티렌옥사이드
니켈
나트륨
Boric acid esters
에틸렌 클로로히드린
장미 기름
브로모벤젠
페닐아세토나이트릴
에틸 페닐아세트산
기름 OF 게라늄
소다의 염산
수소
수산화나트륨
오렌지꽃오일
염화 알루미늄
황산
준비 용품
FEMA 3632
β-브로모에틸벤젠
p-(메톡시에틸)페놀
PHENETHYL SALICYLATE
포름산페닐에틸에스테르
2-PHENYLETHYL PROPIONATE
Phenethyl isobutyrate
Phenethyl phenylacetate
살리실산벤질
FEMA 3222
베타-페닐에틸 아세트산
Metoprolol
콘발라톡신
Phenethyl cinnamate
4-(2-메톡시에틸)페놀
아세토페논
디에틸말산
장미 기름
(2-Methoxyethyl)benzene
Phenylethyl Anthranilate
[[p-(2-메톡시에틸)페녹시]메틸]옥시란
Phenethyl butyrate
FEMA 2871
페닐 아세트알데히드
알파-메틸벤질아세트산
2,5-디클로로아닐린
멜라티온
산화프로필렌
펜에틸알코올 공급 업체
글로벌( 614)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TCI Europe | 320-37350700 |
sales@tcieurope.eu | Europe | 23680 | 75 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5989 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2989 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20294 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales06@airuikechemical.com | China | 983 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
clara@hbshengyang.com | China | 873 | 58 |