2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol
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2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol 속성
- 녹는점
- 192 °C
- 끓는 점
- 590.0±50.0 °C(Predicted)
- 밀도
- 1.0745 (rough estimate)
- 굴절률
- 1.6740 (estimate)
- 저장 조건
- Store at -20°C
- 용해도
- DMSO에 용해됨
- 산도 계수 (pKa)
- pKa1: 7.8; pKa2: 3.65(at 25℃)
- 물리적 상태
- Solid
- 색상
- White to off-white
안전
2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol C화학적 특성, 용도, 생산
Originator
Esucos,UCB Chemie,W. Germany,1962Manufacturing Process
To a suspension of sodamide in liquid ammonia and made from sodium in liquid ammonia, there is added fractionally and with stirring phenothiazine. After an hour there is added thereto, while maintaining the stirring, 1-chloro- 2-methyl-3-bromopropane, then 700 cc of toluene. The ammonia is then driven off and heating under reflux is carried out for one hour.After cooling, water is added and the solution then decanted. The toluene phase is then evaporated in vacuo to constant weight. The residue is constituted of 10-(2-methyl-3-chloro-propyl)-phenothiazine containing acertain quantity of phenothiazine which has not reacted. As this product is not readily soluble in petroleum ether, it is possible to eliminate it by extraction by means of this solvent.
By operating in this manner 10-(2-methyl-3-chloro-propyl)phenothiazine is obtained. A mixture of l0-(2-methyl-3-chloro-propyl)phenothiazine and 1-[2- (2-hydroxyethoxy)ethyl]piperazine is then heated at 110°-120°C for 20 hours. After cooling, the reaction product is dissolved in 200 cc of benzene and the solution washed several times with water.
The benzene phase is then extracted by dilute hydrochloric acid. The acid aqueous phase is decanted, it is made distinctly alkaline and then extracted with benzene. The benzene extract is dried and evaporated in vacuo. The condensation product could not be crystallized. It may be converted into the dihydrochloride which, after recrystallization from isopropanol, melts at 192°C.
Therapeutic Function
Tranquilizer2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol 준비 용품 및 원자재
원자재
준비 용품
2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol 공급 업체
글로벌( 13)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 |
info@pbpharm.com | CHINA | 498 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
MedChemexpress LLC | 021-58955995 |
sales@medchemexpress.cn | United States | 4863 | 58 |
Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 |
lxy2046@yeah.net | China | 480 | 55 |
Aikon International Limited | 025-66028182 18112977050 |
cfzhang@aikonchem.com | China | 15820 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; |
psaitong@jm-bio.com | China | 29778 | 58 |
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 |
1046@dideu.com | China | 10010 | 58 |
TargetMol Chemicals Inc. | 4008200310 |
marketing@tsbiochem.com | China | 23960 | 58 |
https://hanhongsci.com/ | 021-54306202 18917919676 |
info@hanhongsci.com | China | 29978 | 58 |