과이아콜
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과이아콜 속성
- 녹는점
- 26-29 °C (lit.)
- 끓는 점
- 205 °C (lit.)
- 밀도
- 1.129 g/mL at 25 °C (lit.)
- 증기 밀도
- 4.27 (vs air)
- 증기압
- 0.11 mm Hg ( 25 °C)
- 굴절률
- n
20/D 1.543(lit.)
- FEMA
- 2532 | GUAIACOL
- 인화점
- 180 °F
- 저장 조건
- 2-8°C
- 용해도
- H2O: 불용성
- 물리적 상태
- 녹은 후에 액체
- 산도 계수 (pKa)
- 9.98(at 25℃)
- 색상
- 무색투명~연황색
- 수소이온지수(pH)
- 5.4 (10g/l, H2O, 20℃)
- 냄새
- 디프로필렌 글리콜 중 1.00%. 페놀릭 스모크 스파이스 바닐라 우디
- ?? ??
- 페놀성
- Odor Threshold
- 0.0074ppm
- 수용성
- 17g/L(15℃)
- 어는점
- 28℃
- 감도
- Air Sensitive
- JECFA Number
- 713
- Merck
- 14,4553
- BRN
- 508112
- Dielectric constant
- 11.0(-18℃)
- 안정성
- 안정적이지만 공기와 빛에 민감합니다. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
- InChIKey
- LHGVFZTZFXWLCP-UHFFFAOYSA-N
- LogP
- 1.34
- CAS 데이터베이스
- 90-05-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/38 | ||
안전지침서 | 26 | ||
유엔번호(UN No.) | 2810 | ||
WGK 독일 | 1 | ||
RTECS 번호 | SL7525000 | ||
자연 발화 온도 | 750 °C | ||
위험 참고 사항 | Toxic/Irritant | ||
TSCA | Yes | ||
위험 등급 | 6.1(b) | ||
포장분류 | II | ||
HS 번호 | 29095010 | ||
유해 물질 데이터 | 90-05-1(Hazardous Substances Data) | ||
독성 | LD50:900 mg / kg (rat, subcutaneous). LD50: 3.7 mg / kg (rabbit, intravenously). Oral administration of large amount can stimulate the esophagus and stomach, resulting in heart failure, collapse and death. |
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독성 | LD50 orally in rats: 725 mg/kg (Taylor) | ||
기존화학 물질 | KE-23352 |
과이아콜 C화학적 특성, 용도, 생산
화학적 성질
Guaiacol appears as white or slightly yellow crystals or colorless to light yellow transparent oily liquid. It has a distinctive scent. It is slightly soluble in water and benzene, also easily soluble in glycerol. And it is miscible with ethanol, ether, chloroform, oil and glacier acetic acid. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. It is also present in wood smoke, as a product of pyrolysis of lignin.출처
Detected in the distillation product from guaiac resin; guaiacol is found in castoreum oil, in the essential oil from fowers of Pandanus odoratissimus L , in the distillation waters of orange leaves, in the essential oil of Ruta Montana L and in the essential oil of tobacco leaves Also reported found in lemon peel oil, bog blueberry, asparagus, cabbage, celery, onion, chive, tomato, peppermint oil, rye bread, Parmesan cheese, butter, smoked fsh, meats, barley, dried bonito, malt, hardwood smoke, cognac, beer, brandy, rum, whiskies, sherry, grape wines, cocoa, coffee, tea, peanuts, popcorn, soybeans, avocado, beans, mushroom, sesame seed, mango, tamarind, rice dill, licorice, corn oil, cuttlefsh and other sources용도
Guaiacol is a precursor of vanillin and santalidol (a synthetic sandal- wood fragrance). it is obtained from wood tar by the destructive distillation of hardwood, by the distillation of the phenol fraction of coal tar, or through the use of o-dichlorobenzene. it is processed to yield vanillin.정의
ChEBI: Guaiacol is a monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position. It has a role as an expectorant, a disinfectant, a plant metabolite and an EC 1.1.1.25 (shikimate dehydrogenase) inhibitor. It is functionally related to a catechol.제조 방법
Guaiacol can be obtained by diazotization and hydrolysis of anthranium anisole or obtained from fractionated of wood oil.In the nature of guaiacol is presented in the guaiacum or pine oil. In the creosote oil obtained from wood dry distillation, guaiacol is the major ingredient. This product could be obtained through fractional distillation of creosote oil. Japan Osaka Refining Company takes o-nitrochlorobenzene as raw material, first synthesizes o-nitroanisole, and then reduces it to o-anisidine, and finally obtains the goods. China's production method is roughly the same. Ingredient consumption quota: 1250 kg / t of amino-containing anisole, 1500 kg / t of sulfuric acid (93%), 700 kg / t of sodium nitrite and 400 kg / t of copper sulfate.
일반 설명
Guaiacol is a colorless to amber crystals or liquid. Density (of solid) 1.129 g / cm3. Solidifies at 28°C (82.4°F), but may remain liquid for a long time even at a much lower temperature. Slightly water soluble . Soluble in aqueous sodium hydroxide. It is an agent thought to have disinfectant properties and used as an expectorant.공기와 물의 반응
Sensitive to air and light (darkens). Slightly water soluble.반응 프로필
Guaiacol may react with oxidizing materials. Guaiacol forms salts readily with bases.위험도
Toxic by ingestion and skin absorption.화재위험
Guaiacol is combustible.Purification Methods
Crystallise guaiacol from *benzene/pet ether or distil it in a vacuum. [Beilstein 6 H 768, 6 IV 5563.]Toxicity evaluation
LD50:900 mg / kg (rat, subcutaneous).LD50: 3.7 mg / kg (rabbit, intravenously).
Oral administration of large amount can stimulate the esophagus and stomach, resulting in heart failure, collapse and death.
과이아콜 준비 용품 및 원자재
원자재
준비 용품
3,4-디메톡시벤질클로라이드
구아이페네신
2,3-Dihydro-2,2-dimethyl-7-benzofuranol
5-클로로-2-(3,4-디메톡시페닐)-2-이소프로필발레로니트릴
guacetisal
3-Hydroxy-4-methoxybenzaldehyde
DL-4-HYDROXY-3-METHOXYMANDELIC ACID
Guaiacol glycidyl ether
Sulfogaiacol
1-알릴록시-2-메톡시-벤젠
1,2-디메톡시벤젠
2-METHOXYPHENOXYACETIC ACID
Terpinyl cyclohexanol mixture
트리클로산
Homovanillic acid
유게놀
카테콜
3-메틸-2-(3,4-디메톡시페닐)부티로니트릴
4-브로모-2-메톡시페놀
바닐린
과이아콜 공급 업체
글로벌( 825)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hebei Bonster Technology Co.,Limited | +8613315996897 |
bsterltd.wendy@gmail.com | China | 796 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2989 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3320 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12450 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5989 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-17333973358 |
sales06@hbduling.cn | China | 8079 | 58 |
Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 |
sales1@hbganmiao.com | China | 253 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 491 | 58 |
Shandong Juchuang Chemical Co., LTD | +undefined15030412209 |
admin@juchuangchem.com | China | 387 | 58 |