암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)
발암성 물질
구분 2
경고
P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P280
보호장갑/보호의/보안경/안면보호구를 착용하시오.
Adrenocorticotropic hormone C화학적 특성, 용도, 생산
Indications
Adrenocorticotropic hormone (ACTH), or corticotropin,
a peptide of 39 amino acids, is first synthesized
as a larger precursor from which ACTH is derived
by proteolytic cleavage. ACTH stimulates
production of glucocorticoids from the adrenal cortex. Release of ACTH depends on diurnal
rhythms with serum levels highest in the early morning.
Secretion of this peptide also increases under stress. It
is easier and less expensive to treat patients having
adrenocortical insufficiency with glucocorticoid replacement
therapy than it is to use ACTH. Therefore,
use of ACTH (Acthar) is restricted to diagnosis; a
shorter 24–amino acid analogue (Cosyntropin) is also
used. Intravenous administration of ACTH should result
in peak plasma levels of glucocorticoids within 30
to 60 minutes if the adrenal gland is functional.
Prolonged administration of ACTH in a repository
form, however, may be necessary to stimulate steroid
production, because ACTH has long-term trophic effects
on adrenal cells in addition to the rapid stimulation
of steroid production. If the cause of steroid deficiency
is at the level of the pituitary gland, ACTH
should eventually stimulate steroid production.
Biological Functions
The main function of Adrenocorticotropic hormone (ACTH) is to regulate the glucocorticoid (steroid) hormone cortisol. Cortisol is released by the adrenal gland. It regulates blood pressure, blood sugar, the immune system, and the response to stress. This test can help find the causes of certain hormone problems
건강위험
Adrenocorticotropic Hormone (ACTH;Adrenocorticotropin; corticotropic hormone): (1)Maintenance of adrenal cortex;(2)Promotes secretion of steroids, oxidative phosphorylation in adrenal cortex;(3)Mobilizes and increases oxidation of free fatty acid in adipose tissue;(4)Increases gluconeogenesis in liver; increases cyclic adenosine monophosphate (AMP) in adrenal cortex;Decreases urea formation in liver.
Biochem/physiol Actions
Stimulates synthesis and secretion of glucocorticoids by adrenal cortex.
