Levofloxacin
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Levofloxacin 속성
- 녹는점
- 218°C
- 끓는 점
- 572℃
- 밀도
- 1.48±0.1 g/cm3(Predicted)
- 인화점
- >110°(230°F)
- 저장 조건
- Keep in dark place,Sealed in dry,2-8°C
- 용해도
- 클로로포름: 가용성10mg/mL
- 산도 계수 (pKa)
- 5.19±0.40(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 희미한 노란색까지
- optical activity
- [α]20/D -104±4° in chloroform
- 수용성
- 물이나 메탄올에 약간 용해됩니다. 빙초산 또는 디클로로메탄에 용해됨
- 감도
- Light Sensitive
- Merck
- 14,6771
- BRN
- 7327015
- BCS Class
- 3,1
- InChIKey
- GSDSWSVVBLHKDQ-JTQLQIEISA-N
- CAS 데이터베이스
- 100986-85-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22-42/43-68-20/21/22-64-63 | ||
안전지침서 | 26-36/37/39-36 | ||
유엔번호(UN No.) | UN 1648 3 / PGII | ||
WGK 독일 | 3 | ||
RTECS 번호 | UU8815550 | ||
HS 번호 | 29349990 | ||
유해 물질 데이터 | 100986-85-4(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: 1478mg/kg |
Levofloxacin C화학적 특성, 용도, 생산
개요
Levofloxacin, the optically active S-isomer of the fluoroquinolone antibiotic ofloxacin, is two to four times more potent than ofloxacin with reportedly less side effects in treating infections of the lower respiratory and urinary tract, prostate infections and sexually transmitted diseases. It has broad and potent antibacterial activity over common Grampositive and -negative aerobic pathogens and obligate anaerobes. Different from the cephem antibiotics, levofloxacin is unique in its marked selectivity against members of the family Enterobacteriaceae and its negligible effect on predominant anaerobes. Levofloxacin also exhibits satisfactory antimicrobial effects in surgical infections and it may be used for treatment of gastrointestinal infections such as traveler’s diarrhea associated with the pathogenic Enterobacteriaceae.화학적 성질
Slight yellow powder용도
Antibacterial.Antimicrobial activity
Levofloxacin is the active component of ofloxacin; d-ofloxacin is without significant antibacterial activity. It exhibits good activity in vitro against Gram-positive cocci (including Str. pneumoniae), Enterobacteriaceae, some fastidious Gram-negative bacilli and Ps. aeruginosa as well as chlamydiae, Mycoplasma pneumoniae, L. pneumophila and M. tuberculosis. MICs for Acinetobacter spp. and Sten. maltophilia are 0.06–0.25 and 0.5–2.0 mg/L, respectively. Activity against anaerobes is moderate to low.일반 설명
Chemical structure: quinolonePharmaceutical Applications
For molecular weight and structure, see ofloxacin . Levofloxacin is the l-isomer of ofloxacin.Pharmacokinetics
Oral absorption: >95%Cmax 500 mg oral: c. 5 mg/L after 1.5–2 h
750 mg oral: c. 8 mg/L after 1.5–2 h
500 mg intravenous (90-min infusion): c. 6 mg/L end infusion
750 mg intravenous (90-min infusion) :c. 12 mg/L end infusion
Plasma half-life :6–8 h
Volume of distribution:0.6–0.8 L/kg
Plasma protein binding: <25%
Co-administration with antacids, calcium, sucralfate and heavy metals decreases bioavailability and AUC. No interactions with warfarin or theophylline have been observed. Co-administration of a non-steroidal anti-inflammatory drug may increase the risk of convulsions. It undergoes limited metabolism and is primarily eliminated unchanged in urine by both glomerular filtration and tubular secretion. The free AUC:MIC ratio for Str. pneumoniae increases from about 55 to 70 when the daily dosage is raised from 500 mg to 750 mg.
It is stable in plasma and does not revert to d-ofloxacin. It undergoes limited metabolism and is primarily eliminated unchanged in the urine. Renal clearance in excess of the glomerular filtration rate suggests that tubular secretion also occurs. Concomitant administration of either cimetidine or probenecid reduces renal clearance by approximately onethird. Clearance is reduced and half-life is prolonged in patients with impaired renal function (creatinine clearance <50 mL/min) requiring dosage adjustment in such patients.
Clinical Use
Acute bacterial sinusitisAcute bacterial exacerbations of chronic bronchitis, community-acquired pneumonia
Uncomplicated and complicated skin and skin structure infections
Uncomplicated and complicated urinary infections including acute pyelonephritis
Chronic bacterial prostatitis
부작용
Side effects have been reported in 6–7% of patients and include fever, rash and other events common to the group. Elderly patients are at increased risk of developing severe tendon disorders including rupture, a risk increased by concomitant corticosteroid therapy.Levofloxacin 준비 용품 및 원자재
원자재
2,3-DIFLUORO-6-NITROPHENOL
(S)-(+)-1-Amino-2-propanol
P-톨루엔설폰 산
에톡시메틸렌말론산 디에틸에스테르
ETHYL PHENYLPROPIOLATE
2,3,4,5-사불화 벤조익산
N-메틸피페라진
트리플르오르-1,2,3,-4니트로벤젠
황산 하이드록실아민
Liquid chromatography columns
염화 티오닐
리포프로테인리파제
삼불화붕소화합물
무수초산
Aluminium-nickel
준비 용품
Levofloxacin 공급 업체
글로벌( 656)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-17333973358 |
sales06@hbduling.cn | China | 8054 | 58 |
Hebei Dangtong Import and export Co LTD | +86-13910575315 +86-13910575315 |
admin@hbdangtong.com | China | 1005 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 |
sarah@tnjone.com | China | 1143 | 58 |
Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 |
sales@suikangpharm.com | China | 311 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9284 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Levofloxacin 관련 검색:
티오판산-메틸 살리실산 메틸 쿠레톡심메틸 산소, 냉각된 액체 브롬화 메틸 플루오린(불소)
METSULFURON METHYL
Tribenuron methyl
Levofloxacin carboxylic acid, ethyl ester
Levofloxacin carboxylic acid
Levofloxacin heMihydrate
LEVOFLOXACIN HYDROCHLORIDE
N,N'-Desethylene-N,N'-diforMyl Levofloxacin
Levofloxacin Impurity 19
Descarboxyl Levofloxacin
Levofloxacin Impurity 7
Levofloxacin Impurity 21
Levofloxacin Impurity 16