프로게스테론
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프로게스테론 속성
- 녹는점
- 128-132 °C (lit.)
- 끓는 점
- 394.13°C (rough estimate)
- 알파
- 186 º (c=1, ethanol)
- 밀도
- d23 1.166; d20 1.171
- 굴절률
- 182 ° (C=2, Dioxane)
- 인화점
- 2℃
- 저장 조건
- room temp
- 용해도
- H2O: 25 mg/mL, 투명하거나 약간 흐릿할 수 있음
- 물리적 상태
- 가루
- 색상
- 노란색에서 황갈색
- 수용성
- 19ºC에서 <0.1g/100mL
- Merck
- 7773
- BRN
- 1915950
- BCS Class
- 4
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- RJKFOVLPORLFTN-LEKSSAKUSA-N
- LogP
- 3.870
- CAS 데이터베이스
- 57-83-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 40-45-62-36-20/21/22-11 | ||
안전지침서 | 36/37-45-53-16 | ||
유엔번호(UN No.) | UN 1648 3 / PGII | ||
WGK 독일 | 3 | ||
RTECS 번호 | TW0175000 | ||
HS 번호 | 29372390 | ||
유해 물질 데이터 | 57-83-0(Hazardous Substances Data) | ||
독성 | LD50 intraperitoneal in rat: 327mg/kg | ||
기존화학 물질 | KE-29250 |
프로게스테론 C화학적 특성, 용도, 생산
개요
Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-화학적 성질
White powder. Melting point 121°C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity.출처
Colchicum luteum also yields this alkaloid.정의
ChEBI: Progesterone is a C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. It has a role as a contraceptive drug, a progestin, a progesterone receptor agonist, a human metabolite and a mouse metabolite. It is a 20-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid hormone. It derives from a hydride of a pregnane.일반 설명
Progesterone, pregn-4-en-3,20-dione, is so rapidly metabolized that it is not particularlyeffective orally, being only one twelfth as active as intramuscularly.An oral formulation of micronized progesterone(Prometrium) is available. Progesterone given intramuscularlycan be very irritating. A vaginal gel containing 4% or8% progesterone offers an alternative dosage form.Progesterone was originally obtained from animal ovariesbut is now prepared synthetically from plant sterol precursors.The discovery of 19-nortestosterones with progesteroneactivity made synthetically modified progestins of tremendoustherapeutic importance.Progesterone (and all other steroid 4-ene-3-ones) is lightsensitive and should be protected from light.
공기와 물의 반응
Insoluble in water.반응 프로필
Progesterone is sensitive to light .위험도
A carcinogen (OSHA).건강위험
ACUTE/CHRONIC HAZARDS: Progesterone may be absorbed through the skin.화재위험
Flash point data for Progesterone are not available; however, Progesterone is probably combustible.생물학적 활성
Endogenous progesterone receptor (PR) agonist (EC 50 = 0.5 nM).부작용
Common side effects of oral Progesterone include: chest pain, chills, cold or flu-like symptoms; cough or hoarseness; fever, and problems with urination. Rare side effects include: clear or bloody discharge; dimpling of the breast skin, lumps in the breast or armpit; persistent crusting or flaking; redness or swelling of the breast; and sores on the breast skin that do not heal. Other side effects that may occur are: abdominal or stomach pain; constipation, difficulty breathing, dizziness, fast, strong, or irregular heartbeat or pulse; headache, measles, indigestion, itching, joint pain, stiffness, or swelling; rash.Safety Profile
NTP 10th Report on Carcinogens. IARC Cancer Review: Animal Lirmted Evidence IMEMDT 21,491,79; Animal Sufficient Evidence IMEMDT 6,135,74. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory. SAFETY PROFILE: Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intravenous and intraperitoneal routes. Human teratogenic effects by ingestion and parenteral routes: developmental abnormalities of the urogenital system. Human male reproductive effects by intramuscular route: changes in spermatogenesis, the prostate, seminal vesicle, Cowper's gland and accessory glands, impotence, and breast development. Human female reproductive effects by ingestion, parenteral, and intravaginal routes: ferthty changes; menstrual cycle changes and disorders; uterus, cervix, and vagina changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.Carcinogenicity
Progesterone is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.Purification Methods
The form crystallises from EtOH with m 127-131o. The -form crystallises from pet ether or aqueous pet ether/aqueous Et2O with m 119-120o or 121o. It also crystallises from Et2O, Me2CO/EtOAc, MeOH, aqueous Et2O, aqueous MeOH, wet pet ether, Et2O/pet ether, pet ether/*C6H6, Et2O/pentane and isopropyl ether. The is at 240nm with log 4.25 (EtOH). [Wintersteiner & Allen J Biol Chem 107 max 321 1934, Beilstein 7 III 3648, 7 IV 2395.]프로게스테론 준비 용품 및 원자재
원자재
준비 용품
17-Hydroxy-16-methylpregna-5,9(11)-diene-3,20-dione 3,20-diethyleneketal
Deoxycorticosterone acetate
16,17-에폭시프레그나-5,9(11)-디엔-3,20-디온고리형비스(1,2-에탄디일아세탈)
9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-21-acetate
16-데하이드로프로게스테론
17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate
11-α-하이드록시프레근-4-엔-3,20-다이온 및 그 에스터
덱사메타손 아세트산, 무수물
프레그네디온
9,11β-Epoxy-17-hydroxy-16β-methyl-3,20-dioxo-9β-pregna-1,4-diene-21-yl Acetate
메틸4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE
Pregna-4,14-diene-3,20-dione
5α-Pregnane-3,20-dione
4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid
프로게스테론 공급 업체
글로벌( 910)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 |
sales@chembj.net | China | 289 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9316 | 58 |
APOLLO HEALTHCARE RESOURCES | +6596580999 |
sales@apollo-healthcare.com.sg | Singapore | 400 | 58 |
Pharmaceuticals Group Corp., Ltd. | +8613004379774 |
wu@jiaerke.com | China | 33 | 58 |
Senova Technology Co. Ltd. | +86-0755-86703119 +8618503098836 |
info@senovatech.com | China | 351 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@sdzhonghuimaterial.com | China | 983 | 58 |
Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 |
3684455296@qq.com | China | 9311 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 295 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5987 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 |
Ethan@dornechem.com | China | 3128 | 58 |