6-Nitroveratraldehyde
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6-Nitroveratraldehyde 속성
- 녹는점
- 131-133 °C (lit.)
- 끓는 점
- 350.84°C (rough estimate)
- 밀도
- 1.4194 (rough estimate)
- 굴절률
- 1.5700 (estimate)
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- DMSO: 22mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 노란색
- 수용성
- 물에 불용성. 부드럽게 가열하면 에탄올에 25mM, DMSO에 100mM까지 용해됩니다.
- 감도
- Air & Light Sensitive
- BRN
- 395599
- CAS 데이터베이스
- 20357-25-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
6-Nitroveratraldehyde C화학적 특성, 용도, 생산
화학적 성질
yellow fluffy powder용도
6-Nitroveratraldehyde has been used in the preparation of no-carrier-added 6-18F-fluoro-L-dopa, fundamental tracer for cerebral positron emission tomography studies of dopaminergic system in humans and o-nitroaryl-bis(5-methylfur-2-yl)methanes, versatile synthons for the synthesis of nitrogen-containing heterocycles. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair. It is also used for synthesizing analogs of alpha-asarone.일반 설명
A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) activity (IC50 = 15 μM) and DNA-PK-mediated double strand break (DSB) DNA repair by non-homologous DNA-end-joining (NHEJ). Reported to effectively sensitize cells to Cisplatin (Cat. No. 232120). Does not affect the activities of PKC or Chk2.생물학적 활성
Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC 50 = 15 μ M), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.Purification Methods
The aldehyde is purified by dissolving 9g in 200mL of boiling 95% EtOH, and set aside overnight to crystallise. It is then dried in vacuo at 50o and recrystallised from 110mL of 95% EtOH to give 6-7g of aldehyde with m 132-133o. Crystallisation from aqueous EtOH provides light yellow needles. It is light sensitive and should be stored in the dark [Fetscher Org Synth Coll Vol 4 735 1963]. [Beilstein 8 H 262, 8 I 610, 8 II 290, 6 III 2065, 6 IV 1785.]6-Nitroveratraldehyde 준비 용품 및 원자재
원자재
Benzenemethanamine, 4,5-dimethoxy-2-nitro-
4-히드록시-5-메톡시-2-니트로벤즈알데히드
4,5-디메톡시-2-니트로벤질브로마이드
4,5-다이메톡시-2-니트로벤질알코올
3,4-디메톡시벤즈알데히드
파라-티오크레솔
바닐린
아세트산(빙초산)
준비 용품
6-Nitroveratraldehyde 공급 업체
글로벌( 287)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12459 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20314 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21670 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 |
sales@ansciepchem.com | CHINA | 4242 | 58 |
Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8826 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |