NU 2058
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NU 2058 속성
- 녹는점
- 199°C(lit.)
- 끓는 점
- 424.8±55.0 °C(Predicted)
- 밀도
- 1.52±0.1 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Sealed in dry,2-8°C
- 용해도
- DMSO: 22mg/mL
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 7.36±0.20(Predicted)
- 색상
- 하얀색
- 최대 파장(λmax)
- 281nm(MeOH)(lit.)
- InChIKey
- MWGXGTJJAOZBNW-UHFFFAOYSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
NU 2058 C화학적 특성, 용도, 생산
개요
NU 2058 is an inhibitor of cyclin-dependent kinase 1 (Cdk1) and Cdk2 (IC50s = 7.0 and 17 μM, respectively). Increased Cdk activity is often associated with human tumors, and inhibitors of Cdks, including NU 2058, can arrest cell cycling in cancer cells in vitro.용도
NU 2058 is an intermediate of NU 6140 (N925295), a cyclin-dependant kinase 2 inhibitor which demonstrates 10-36 fold selectivity against Cdk2-cyclin A. This selectivity induces cell-cycle arrest at the G2-M phase and potentiates the apoptotic effect of pacitaxel.생물학적 활성
Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (K i values are 5 and 12 μ M respectively). Inhibits growth of human tumor cells in vitro (mean GI 50 = 13 μ M). Also inhibits DNA topoisomerase II ATPase activity (IC 50 = 300 μ M).NU 2058 준비 용품 및 원자재
원자재
준비 용품
NU 2058 공급 업체
글로벌( 94)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29826 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 |
sales@anbuchem.com | China | 3000 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10978 | 58 |
NU 2058 관련 검색:
2-메시틸렌설포닐 염화물
Roscovitine
PD0332991 Isethionate
BUTYROLACTONE I
PROSTAGLANDIN A2
Flavopiridol
Cdk Inhibitor, p35
Palbociclib
H-ALA-ASP-ALA-GLN-HIS-ALA-THR-PRO-PRO-LYS-LYS-LYS-ARG-LYS-VAL-GLU-ASP-PRO-LYS-ASP-PHE-OH
BML-259
6-Methoxyguanine
6-N-PROPOXYPURINE
NU6140
6-N-BUTOXYPURINE
6-ETHOXYPURINE
NU 2058
NU6102