부티로락톤I
|
|
부티로락톤I 속성
- 녹는점
- 74℃
- 끓는 점
- 660.1±55.0 °C(Predicted)
- 밀도
- 1.353±0.06 g/cm3(Predicted)
- RTECS 번호
- LU0221600
- 저장 조건
- Store at -20°C
- 용해도
- 25mg/ml의 에탄올 또는 10mg/ml의 DMSO에 용해됨
- 물리적 상태
- 백색 고체.
- 산도 계수 (pKa)
- 8.59±0.40(Predicted)
- 색상
- 흰색에서 황백색까지
- 감도
- Light Sensitive
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| HS 번호 | 29419000 |
|---|
| 그림문자(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 신호 어: | |||||||||||||||||||||||||||||
| 유해·위험 문구: |
|
||||||||||||||||||||||||||||
| 예방조치문구: |
|
부티로락톤I C화학적 특성, 용도, 생산
용도
Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.효소 저해제
This natural product (FW = 424.45 g/mol), first identified in species of Aspergillus and named systematically as 2,5-dihydro-4-hydroxy 2-([4- hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl)-3-(4-hydroxyphenyl)-5-oxo- 2-furancarboxylic acid methyl ester, competes with ATP in cyclindependent kinase reactions. The IC50 values for these kinases are typically 0.6-1.5 μM. Butyrolactone I also inhibits cell proliferation by the inhibiting pRb phosphorylation in IMR32 cells, causing both G1 and G2 arrest and stimulating apoptosis. Target(s): cyclin-dependent kinases 1 and 2; cdk5; protein kinase C; protein kinase A; MAP kinase; casein kinase II; [tau protein] kinase.부티로락톤I 준비 용품 및 원자재
원자재
준비 용품
부티로락톤I 공급 업체
글로벌( 26)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21676 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
| Alfa Chemistry | +1-5166625404 |
Info@alfa-chemistry.com | United States | 21317 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 |
Ryan@jiutian-bio.com | China | 7432 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Winherb Medical Technology Co., Ltd. | 400-186-5138 13341702378 |
winherb@126.com | China | 1006 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9708 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 |
info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 |
info@novachemistry.com | United Kingdom | 4381 | 58 |
부티로락톤I 관련 검색:
Roscovitine
PD0332991 Isethionate
PROSTAGLANDIN A2
Flavopiridol
Cdk Inhibitor, p35
Palbociclib
H-ALA-ASP-ALA-GLN-HIS-ALA-THR-PRO-PRO-LYS-LYS-LYS-ARG-LYS-VAL-GLU-ASP-PRO-LYS-ASP-PHE-OH
NU 2058
BML-259
3-(4-Hydroxyphenyl)lactate
Phenethyl cinnamate
4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
3-Hydroxy-4-methyl-5-ethyl-2(5H)furanone
2-ACETOXY-3-PHENYL-PROPIONIC ACID
BUTYROLACTONE I
2,5-DIHYDRO-FURAN-2-CARBOXYLIC ACID
3-(4-HYDROXYPHENYL)-2-METHOXYPROPANOIC ACID