BUTYROLACTONE I
- CAS No.
- 87414-49-1
- Chemical Name:
- BUTYROLACTONE I
- Synonyms
- OloMoucin;BUTYROLACTONE I;Butyrolactone I - CAS 87414-49-1;2,5-Dihydro-4-hydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)benzyl]-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester;2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-
- CBNumber:
- CB9717987
- Molecular Formula:
- C24H24O7
- Molecular Weight:
- 424.44
- MDL Number:
- MFCD03453074
- MOL File:
- 87414-49-1.mol
| Melting point | 74℃ |
|---|---|
| Boiling point | 660.1±55.0 °C(Predicted) |
| Density | 1.353±0.06 g/cm3(Predicted) |
| RTECS | LU0221600 |
| storage temp. | Store at -20°C |
| solubility | Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml |
| form | White solid. |
| pka | 8.59±0.40(Predicted) |
| color | White to off-white |
| Sensitive | Light Sensitive |
| FDA UNII | HKM4266XIK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| HS Code | 29419000 |
BUTYROLACTONE I price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 203988 | Butyrolactone I - CAS 87414-49-1 - Calbiochem A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G?/S and G?/M transitions. | 87414-49-1 | 200μG | $251 | 2023-06-20 | Buy |
| Alfa Aesar | J67151 | Butyrolactone I, 98% | 87414-49-1 | 200microg | $162 | 2021-12-16 | Buy |
| Cayman Chemical | 21765 | Butyrolactone I ≥95% | 87414-49-1 | 1mg | $186 | 2024-03-01 | Buy |
| Cayman Chemical | 21765 | Butyrolactone I ≥95% | 87414-49-1 | 5mg | $556 | 2024-03-01 | Buy |
| TRC | B161388 | ButyrolactoneI | 87414-49-1 | 200μg | $90 | 2021-12-16 | Buy |
BUTYROLACTONE I Chemical Properties,Uses,Production
Uses
Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.
Enzyme inhibitor
This natural product (FW = 424.45 g/mol), first identified in species of Aspergillus and named systematically as 2,5-dihydro-4-hydroxy 2-([4- hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl)-3-(4-hydroxyphenyl)-5-oxo- 2-furancarboxylic acid methyl ester, competes with ATP in cyclindependent kinase reactions. The IC50 values for these kinases are typically 0.6-1.5 μM. Butyrolactone I also inhibits cell proliferation by the inhibiting pRb phosphorylation in IMR32 cells, causing both G1 and G2 arrest and stimulating apoptosis. Target(s): cyclin-dependent kinases 1 and 2; cdk5; protein kinase C; protein kinase A; MAP kinase; casein kinase II; [tau protein] kinase.
storage
+4°C
BUTYROLACTONE I Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21677 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 7432 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Winherb Medical Technology Co., Ltd. | 400-186-5138 13341702378 | winherb@126.com | China | 1008 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
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