2-Iodoaniline
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2-Iodoaniline 속성
- 녹는점
- 55-58 °C (lit.)
- 끓는 점
- 262.0±23.0 °C(Predicted)
- 밀도
- 1.8155 (estimate)
- 인화점
- >230 °F
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- soluble in Chloroform, DCM, Ethyl Acetate, Toluene
- 물리적 상태
- 니들 크리스탈
- 산도 계수 (pKa)
- 2.6(at 25℃)
- 색상
- 노란색에서 갈색으로
- 수용성
- 물에 불용성.
- 감도
- Light Sensitive
- BRN
- 2204899
- InChIKey
- UBPDKIDWEADHPP-UHFFFAOYSA-N
- CAS 데이터베이스
- 615-43-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20/21/22-37/38-36/37/38 | ||
| 안전지침서 | 36/37-36/37/39-26-36 | ||
| 유엔번호(UN No.) | 2811 | ||
| WGK 독일 | 3 | ||
| F 고인화성물질 | 8 | ||
| 위험 참고 사항 | Irritant | ||
| TSCA | T | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29214210 |
2-Iodoaniline C화학적 특성, 용도, 생산
화학적 성질
YELLOW TO BROWN CRYSTALLINE NEEDLES용도
2-Iodoaniline is used as an intermediate in organic synthesis.제조 방법
2-iodoaniline and its derivatives are commonly used for the preparation of indole-based anticancer drugs, which have high market value, and further synthesis can lead to high-end synthetic intermediates with complex structures.Take a reaction tube, add 50mg of sodium azide, 75mg of 1-(2-iodophenyl)ethanol, 300uL of trifluoroacetic acid, 150uL of methanesulfonic acid and 1.0mL of hexane, and stir for 24 hours at 40℃. After the reaction, 10 mL of sodium hydroxide solution was added to quench the reaction. The organic phase was washed with 5 mL of brine, and the organic phase was combined and separated by column chromatography to obtain 58.4 mg of 2-iodoaniline in 89% yield.
Synthesis of 2-iodoaniline
Purification Methods
Distil 2-iodoaniline with steam and crystallise it from *benzene/pet ether. The N-acetyl derivative has m 110o. [Beilstein 12 IV 1542.]2-Iodoaniline 준비 용품 및 원자재
원자재
준비 용품
2-Iodoaniline 공급 업체
글로벌( 498)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Dalian Richfortune Chemicals Co., Ltd | 0411-84820922 8613904096939 |
sales@richfortunechem.com | China | 304 | 57 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12460 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20318 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +86-86177 |
admin@hbouhuang.com | China | 2952 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16208 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21673 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29897 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 |
stella@zetchem.com | China | 2141 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10318 | 58 |