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4-나이트로아닐린

4-나이트로아닐린 구조식 이미지

카스 번호:: 100-01-6

한글명:: 4-나이트로아닐린

동의어(한글):: 4-나이트로아닐린;4-니트로아닐린;p-나이트로아닐린;p-니트로아닐린;1-아미노-4-니트로벤젠;p-아미노나이트로벤젠

상품명:: 4-Nitroaniline

동의어(영문):: PNA;P-NITROANILINE;PARA NITRO ANILINE;4-NITROBENZENAMINE;P-nitroanilide;4-Nitro-phenylamine;P-NITROPHENYLAMINE;red2gbase;developerp;devolredgg

CBNumber:: CB9852549

분자식:: C6H6N2O2

포뮬러 무게:: 138.12

MOL 파일:: 100-01-6.mol

MSDS 파일:: SDS

속성

안전

MSDS

용도

4-나이트로아닐린 속성

녹는점: 147 °C

끓는 점: 332 °C

밀도: 1,437 g/cm³

벌크 밀도: 630kg/m3

증기 밀도: 4.77 (vs air)

증기압: 1.33 hPa (142 °C)

굴절률: 1.6465 (estimate)

인화점: 329 °F

저장 조건: Store below +30°C.

용해도: 에탄올: 가용성 25mg/mL, 약간 흐릿함, 노란색에서 갈색을 띤 노란색

산도 계수 (pKa): 1(at 25℃)

색상 색인 번호: 37035

물리적 상태: 수정 같은

색상: 노란색

Specific Gravity: 1.437

냄새: 암모니아 냄새

pH 범위: 7

수용성: 0.8g/L(20℃)

Merck: 14,6584

BRN: 508690

Henry's Law Constant: 1.15 x 10^-9 atm?m³/mol at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)

노출 한도: NIOSH REL: TWA 3; IDLH 300; OSHA PEL: TWA 6; ACGIH TLV: TWA 3 (adopted).

Dielectric constant: 56.3（160.0℃）

안정성: 안정적인. 수산화나트륨, 강산화제, 강환원제와 혼합할 수 없습니다. 일부 플라스틱, 고무 및 코팅을 공격할 수 있습니다. 개시제 존재 시 폭발적으로 분해될 수 있습니다. 수분에 민감합니다. 가볍고 공기에 민감할 수 있습니다.

LogP: 1.2 at 30℃

CAS 데이터베이스: 100-01-6(CAS DataBase Reference)

NIST: p-Nitroaniline(100-01-6)

EPA: p-Nitroaniline (100-01-6)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	T,F
위험 카페고리 넘버	23/24/25-33-52/53-39/23/24/25-11
안전지침서	28-36/37-45-61-28A-16-1/2-7
유엔번호(UN No.)	UN 1661 6.1/PG 2
OEB	B
OEL	TWA: 3 mg/m3 [skin]
WGK 독일	2
RTECS 번호	BY7000000
F 고인화성물질	8
자연 발화 온도	500 °C
위험 참고 사항	Toxic
TSCA	Yes
위험 등급	6.1
포장분류	II
HS 번호	29214210
유해 물질 데이터	100-01-6(Hazardous Substances Data)
독성	Acute LD₅₀ for wild birds 75 mg/kg, guinea pigs 450 mg/kg, mice 810 mg/kg, quail 1,000 mg/kg, rats 750 mg/kg (quoted, RTECS, 1985).
IDLA	300 mg/m3
기존화학 물질	KE-25964

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H373	장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음	특정 표적장기 독성 - 반복 노출	구분 2	경고		P260, P314, P501
H412	장기적 영향에 의해 수생생물에 유해함	수생 환경유해성 물질 - 만성	구분 3			P273, P501

예방조치문구:

P273	환경으로 배출하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P310	삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P314	불편함을 느끼면 의학적인 조치·조언을 구하시오.

NFPA 704

	1
3		2

4-나이트로아닐린 MSDS

4-Nitroaniline

4-나이트로아닐린 C화학적 특성, 용도, 생산

화학적 성질

Yellow fine crystals

물리적 성질

Bright yellow crystalline powder or flakes with a faint, ammonia-like, slightly pungent odor. Combustible.

용도

4-Nitroaniline is used in the synthesis of photorefractive polymers, as novel chromophores in analytical study. As well, due to the absorption spectrum associated with 4-Nitroaniline, it is used to de termine catechol derivatives in syntheses.

정의

ChEBI: A nitroaniline carrying a nitro group at position 4.

일반 설명

Yellow solid with a mild odor. Sinks in water.

공기와 물의 반응

4-Nitroaniline may be sensitive to prolonged exposure to air and light. Insoluble in water. 4-Nitroaniline is sensitive to moisture.

반응 프로필

P-NITROANILINE may react vigorously with sulfuric acid above 392° F. 4-Nitroaniline may also react with sodium hydroxide at 266° F. Under pressure, 4-Nitroaniline may produce an explosive compound. 4-Nitroaniline is incompatible with strong oxidizers and strong reducing agents. 4-Nitroaniline is capable of explosive decomposition with strong initiators. 4-Nitroaniline will attack some forms of plastics, rubber and coatings.

위험도

Explosion risk. Toxic when absorbed by skin. Methemoglobinemia, liver damage and eye irritant. Questionable carcinogen.

건강위험

Inhalation or ingestion causes headache, drowsiness, shortness of breath, nausea, methemoglobinemia, and unconsciousness; fingernails, lips, and ears become bluish; prolonged and excessive exposures may also cause liver damage. Contact with eyes causes irritation and possible corneal damage. Contact with skin causes irritation; continued exposure may cause same symptoms as inhalation or ingestion.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by intramuscular route. Mutation data reported. Acute symptoms of exposure are headache, nausea, vomiting, weakness and stupor, cyanosis and methemoglobinemia. Chronic exposure can cause liver damage. Experimental reproductive effects. Combustible when exposed to heat or flame. See NITRATES for explosion and disaster hazards. To fight fire, use water spray or mist, foam, dry chemical, CO2. Vigorous reaction with sulfuric acid above 200°C. Reaction with sodium hydroxide at 13O°C under pressure may produce the explosive sodium-4-nitrophenoxide. When heated to decomposition it emits toxic fumes of NOx. See also m- NITROANILINE, o-NITROANILINE, NITRO COMPOUNDS OF AROMATIC HYDROCARBONS, and ANILINE DYES.

잠재적 노출

p-Nitroaniline is used as an intermediate in the manufacture of dyes; antioxidants, pharmaceuticals, antiozonants, colors, pigments and pesticides.

Carcinogenicity

p-Nitroaniline has been tested in several strains of S. typhimurium. It was mutagenic in strain TA98 but not in strains TA97, TA100, TA1535, and TA1537, with and without S9. It caused gene mutation in mouse lymphoma cells and chromosomal aberrations in CHO cells in the presence of S9.

환경귀착

Biological. A Pseudomonas sp. strain P6, isolated from a Matapeake silt loam, was grown using a yeast extract. After 8 d, 4-nitroaniline degraded completely to carbon dioxide (Zeyer and Kearney, 1983). In activated sludge inoculum, following a 20-d adaptation period, no degradation was observed (Pitter, 1976).
Chemical/Physical: Spacek et al. (1995) investigated the photodegradation of 4-nitroaniline using titanium dioxide-UV light and Fenton’s reagent (hydrogen peroxide:substance – 10:1; Fe2+ 2.5 x 10^-4 mol/L). Both experiments were conducted at 25 °C. The decomposition rate of 4-nitroaniline was very high by the photo-Fenton reaction in comparison to titanium dioxide-UV light (λ = 365 nm). Decomposition products identified in both reactions were nitrobenzene, pbenzoquinone, hydroquinone, oxalic acid, and resorcinol. Oxalic acid, hydroquinone, and pbenzoquinone were identified as intermediate products using HPLC.
At influent concentrations of 10, 1.0, 0.1, and 0.01 mg/L, the GAC adsorption capacities were 250, 140, 74, and 40 mg/g, respectively (Dobbs and Cohen, 1980).

운송 방법

UN1661 Nitroanilines (m-, o-, p-), Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

It also crystallises from acetone. It is freed from o-and m-isomers by zone melting and sublimation. [Beilstein 12 IV 1613.]

비 호환성

A combustible liquid. A strong oxidizer. Incompatible with strong acids; sulfur, combustibles, organics, and other easily oxidizable materials. Will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion.

폐기물 처리

Incineration (982℃, 2.0 seconds minimum) with scrubbing for nitrogen oxides abatement. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

4-나이트로아닐린 준비 용품 및 원자재

원자재

2-벤조일아세트아닐리드 P-클로로니트로벤젠 물 암모니아(가스)

준비 용품

디스페스 오렌지 25 Direct Grey D 나프톨 BLUE BLACK 암사크린 AMIDO GREEN BLACK B 피리미닐 DIRECT FAST BLACK G 4-Nitrophenyl isocyanate Disperse Red 135 3-CHLORO-6-NITROQUINOLINE Direct Green 26 disodium 4-[[2,4-diamino-5-[(3-sulphonatophenyl)azo]phenyl]azo]-2-[[2,6-dihydroxy-3-[(4-nitrophenyl)azo]phenyl]azo]benzenesulphonate Fast Black Base LS 파라-디니트로 벤젠 CADION Disperse Red 74 SIRIUS YELLOW GC 분산적색17호 C.I. 다이렉트 블랙 019 Disperse Red S-2GFL DISPERSE BLACK 1 N-(4,6-DIMETHYLPYRIMIDIN-2-YL)BENZENE-1,4-DIAMINE Disperse Orange 29 Disperse Orange 73 C.I. 산 블랙 210 Disperse Orange 37 Disperse Scarlet SE-R N-BOC-L-류실글리실-아르기닌-p-니트로아닐리드염산염 3-CHLOROQUINOLIN-6-AMINE N-(4-NITROPHENYL)-4,6-DIMETHYL-2-PYRIMIDINAMINE 6-Aminoquinoline 4-(4-니트로페닐아조)-N-(2-시아노에틸)-N-(2-아세톡시에틸)아닐린 다이렉트그린89 Disperse Blue 183 카토닉다크옐로우2RL 메틸N-[4-[(2-클로로-4-니트로페닐)아조]페닐]-N-(2-시아노에틸)-베타-알라니네이트 2-BROMO-4-NITROANILINE FAST 블랙 염 Acid Brown 75 [2-[에틸[4-[(4-니트로페닐)아조]페닐]아미노]에틸]트리메틸암모늄클로라이드