퀴날도펩틴

퀴날도펩틴
퀴날도펩틴 구조식 이미지
카스 번호:
130743-07-6
한글명:
퀴날도펩틴
동의어(한글):
퀴날도펩틴
상품명:
quinaldopeptin
동의어(영문):
quinaldopeptin;BMY 28662, BU 3845T;Quinaldopeptin (9CI)
CBNumber:
CB51318925
분자식:
C62H78N14O14
포뮬러 무게:
1243.38
MOL 파일:
130743-07-6.mol

퀴날도펩틴 속성

밀도
1.45±0.1 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
DMF: soluble; DMSO: soluble; Ethanol: slightly soluble; Methanol: slightly soluble
물리적 상태
노란색 가루.
산도 계수 (pKa)
6.91±0.40(Predicted)

안전

퀴날도펩틴 C화학적 특성, 용도, 생산

개요

Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1, and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).

용도

Quinaldopeptin is a symmetrical, cyclic decapeptide from an Amycolatopsis sp. that is a bis-intercalator of DNA, exhibiting strong in vitro antimicrobial and cytotoxic activity. Quinaldopeptin significantly prolongs the survival time of mice inoculated with a murine tumour, and also shows weak nematocidal activity. Quinaldopeptin is related to the luzopeptins and sandramycin.

퀴날도펩틴 준비 용품 및 원자재

원자재

준비 용품


퀴날도펩틴 공급 업체

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