Cyclophosphamide monohydrate is used to treat cancers, autoimmune disorders and AL amyloidosis. It is a nitrogen mustard alkylating agent and reacts with deoxyribonucleic acid (DNA) to get its alkylated derivative. It is also involved in cancer research as a tool that induces apoptosis in tumor cells.
정의
ChEBI: The monohydrate of cyclophosphamide.
일반 설명
Fine white crystalline powder with a slightly bitter taste. Little or no odor.
공기와 물의 반응
Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions.
반응 프로필
Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis.
화재위험
Cyclophosphamide monohydrate is probably combustible.
Safety Profile
Confirmed human
carcinogen. Poison by ingestion and
intravenous routes. Experimental
reproductive effects. Mutation data
reported. When heated to decomposition it
emits toxic fumes of Cl-, PO,, and NOx.
