4-Methylimidazole
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4-Methylimidazole 속성
- 녹는점
- 44-47 °C(lit.)
- 끓는 점
- 263 °C(lit.)
- 밀도
- 1.02
- 굴절률
- 1.5037
- 인화점
- >230 °F
- 저장 조건
- 2-8°C
- 용해도
- H2O: 용해성, 투명, 무색~노란색(50mg/mL)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- pK1:7.55(＋1) (25°C)
- 색상
- 적갈색~녹색~갈색
- 수용성
- 물에 용해됩니다.
- BRN
- 1453
- InChIKey
- XLSZMDLNRCVEIJ-UHFFFAOYSA-N
- LogP
- 0.230
- CAS 데이터베이스
- 822-36-6(CAS DataBase Reference)
- IARC
- 2B (Vol. 101) 2013
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | C | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 21/22-34-22 | ||
| 안전지침서 | 26-36/37/39-45-25 | ||
| 유엔번호(UN No.) | UN 3263 8/PG 3 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | NI7350000 | ||
| TSCA | Yes | ||
| 위험 등급 | 8 | ||
| 포장분류 | III | ||
| HS 번호 | 29339900 | ||
| 유해 물질 데이터 | 822-36-6(Hazardous Substances Data) | ||
| 기존화학 물질 | KE-24300 |
4-Methylimidazole C화학적 특성, 용도, 생산
화학적 성질
Slightly yellow chunks. soluble in water and ethanol.용도
4-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 4-Methylimidazole is a product which results f rom the interaction of reducing sugars with ammonia. 4-Methylimidazole showed convulsant activity in animals and is listed as a possible carcinogen.정의
ChEBI: 4-methylimidazole is imidazole substituted at position 4 by a methyl group. It has a role as a carcinogenic agent and a reaction intermediate.제조 방법
4-Methylimidazole is synthesized by the reaction of glyoxal, acetaldehyde and ammonia. Another method to synthesize the compound is by catalytic dehydrogenation of imidazoline derivatives. 4-Methylimidazole may be synthesized from propanol and formamide, by catalytic cyclization of bisformamidipropane or by photolysis of alkenyltetrazole derived from alkenes by sequential epoxidation, ring opening and dehydration (NTP, 2007).일반 설명
4(5)-Methylimidazole was quantified in coffee by GC-MS method.부작용
4-Methylimidazole is an eye irritant, causes burns, may cause corrosive damage to the upper respiratory tract and lungs if inhaled, and is harmful if ingested.In vivo findings: No histopathological changes were observed in 15-day oral studies in rats and mice. A 14-week oral study showed tremors, ataxia, anaemia, vacuolisation of hepatocytes and testicular degeneration in rats and anaemia, vacuolisation of hepatocytoplasm and renal degeneration in mice.
Histopathological liver changes were also observed in a 106-week oral study in rats, causing neurological effects including hyperexcitability, convulsions and seizures in livestock and experimental animals. Reproductive organ toxicity and reduced fertility were observed in male rats.
Evidence of carcinogenicity: no carcinogenicity in male rats; ambiguous in female rats; clear evidence in male and female mice; irritating or corrosive to rabbit skin.
Purification Methods
Recrystallise 4-methylimidazole from *benzene or pet ether. It has m 56o after sublimation. The picrate has m 162-163.5o (from EtOH). [Beilstein 23 II 60, 23 III/IV 597, 23/5 V 89.]4-Methylimidazole 준비 용품 및 원자재
원자재
준비 용품
4-Methylimidazole 공급 업체
글로벌( 589)공급 업체
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