Pomalidomide-C6-PEG3-butyl iodide
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Pomalidomide-C6-PEG3-butyl iodide 속성
- 끓는 점
- 813.9±65.0 °C(Predicted)
- 밀도
- 1.446±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 산도 계수 (pKa)
- 10.69±0.40(Predicted)
안전
Pomalidomide-C6-PEG3-butyl iodide C화학적 특성, 용도, 생산
용도
Protein degrader builiding block Pomalidomide-C6-PEG3-butyl iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Pomalidomide-C6-PEG3-butyl iodide 준비 용품 및 원자재
원자재
준비 용품
Pomalidomide-C6-PEG3-butyl iodide 공급 업체
글로벌( 10)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 |
info@chemextension.com | China | 42056 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 |
1924344760@confluore.cn | China | 2995 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51456 | 80 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 |
1924344760@qq.com | China | 4824 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 |
1927928688@qq.com | China | 1456 | 58 |
| Shaanxi borno biotechnology co., LTD | +86-13759708231 |
asherw9@hotmail.com | China | 2350 | 58 |
| Zhengzhou convergence chemical co., LTD | 0371-0371-55153829 18003835034 |
2853979819@qq.com | China | 9718 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 |
czbjpharma@126.com | China | 18478 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 13417589054 |
trendseenbio@gmail.com | China | 9470 | 58 |
| Xi‘an Deeptech Biotechnology Co.,LTD | +86-15114901355 +86-15114901355 |
15114901355@163.com | China | 189 | 58 |
Pomalidomide-C6-PEG3-butyl iodide 관련 검색:
E3 ligase Ligand-Linker Conjugates 49
6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid
Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
E3 ligase Ligand-Linker Conjugates 55
1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
Pomalidomide-6-2-2-6-N3
Pomalidomide-amido-C1-Br
Pomalidomide-C6-NH2?hydrochloride
Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
POMALIDOMIDE-C9-CO2H