TCPOBOP

TCPOBOP 구조식 이미지
카스 번호:
76150-91-9
상품명:
TCPOBOP
동의어(영문):
TCPOBOP;3,3',5,5'-TETRACHLORIDE-BPB;TCPOBOP - CAS 76150-91-9 - Calbiochem;inhibit,Bcl-2 Family,TCPOBOP,Inhibitor;1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene;1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE;1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene;3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE;1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene;3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene
CBNumber:
CB8155924
분자식:
C16H8Cl4N2O2
포뮬러 무게:
402.06
MOL 파일:
76150-91-9.mol
MSDS 파일:
SDS

TCPOBOP 속성

끓는 점
444.8±45.0 °C(Predicted)
밀도
1.518±0.06 g/cm3(Predicted)
저장 조건
2-8°C
용해도
DMSO: >10mg/mL
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
-0.52±0.10(Predicted)
색상
하얀색
안정성
제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO의 솔루션은 -20°C에서 최대 1주일 동안 보관할 수 있습니다.

안전

안전지침서 22-24/25
WGK 독일 3
RTECS 번호 UT7145000

TCPOBOP C화학적 특성, 용도, 생산

용도

TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins.

일반 설명

A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.

Biochem/physiol Actions

TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.

TCPOBOP 준비 용품 및 원자재

원자재

준비 용품


TCPOBOP 공급 업체

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