Sertraline hydrochloride is a selective serotonin reuptake inhibitor, similar mechanistically
to fluoxetine, introduced initially for the maintenance and long-term treatment of
depression. It is reportedly non-sedating and compared to fluoxetine has a shorter duration
of action and lack of CNS activating effects such as nervousness and anxiety. Sertraline
hydrochloride is currently undergoing investigation for the treatment of obesity and
obsessive-compulsive disorders.
화학적 성질
White or almost white, crystalline powder.
용도
The effect of exposure of sertraline hydrochloride was studied in chronically prepared ovine fetus. It was used in glucocorticoid function assay to study the effect of antidepressants on glucocorticoid receptor function in humans.
정의
ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of sertraline and hydrogen chloride. A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as an antidepressant for the treatment of depression, obsessive-compulsive diso
der, panic disorder and post-traumatic stress disorder.
일반 설명
Sertraline, marketed as the brand drug Zoloft?, is an SSRI antidepressant used in the treatment of major depression as well as obsessive-compulsive, panic, and social anxiety disorders. This Certified Snap-N-Spike? Solution is applicable for use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology, and forensic analysis.
생물학적 활성
Potent, orally active selective serotonin re-uptake inhibitor (SSRI) used clinically to treat depression.
