티민
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티민 속성
- 녹는점
- ~320 °C (dec.) (lit.)
- 끓는 점
- 234.21°C (rough estimate)
- 밀도
- 1.3541 (rough estimate)
- 굴절률
- 1.5090 (estimate)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨, 가열)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 9.94(at 25℃)
- 색상
- 하얀색
- 수용성
- 뜨거운 물에 용해됩니다. 알코올에 약간 용해됩니다.
- 분해온도
- 335 °C
- Merck
- 14,9398
- BRN
- 607626
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- RWQNBRDOKXIBIV-UHFFFAOYSA-N
- LogP
- -0.620
- CAS 데이터베이스
- 65-71-4(CAS DataBase Reference)
- NIST
- Thymine(65-71-4)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36-36/37/38 | ||
| 안전지침서 | 22-24/25-37/39-26 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | XP2100000 | ||
| TSCA | Yes | ||
| HS 번호 | 29335990 | ||
| 기존화학 물질 | KE-25319 |
티민 C화학적 특성, 용도, 생산
화학적 성질
White, crystalline powder. Slightly soluble in hot water; insoluble in coldwater, alcohol; sparingly soluble in ether; readily soluble in alkalies.용도
Thymine is a nitrogenous base component in the nucleic acid of DNA.정의
thymine: A pyrimidine derivativeand one of the major componentbases of nucleotides and the nucleicacid DNA.일반 설명
Thymine (Zidovudine Related Compound C) is a process related impurity of antiretroviral drug zidovudine. Zidovudine belongs to the class of drugs known as nucleoside reverse transcriptase inhibitors and is generally used in the prevention and treatment of HIV/AIDS.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Purification Methods
Crystallise thymine from EtOAc, 10% aqueous EtOH or water. It has m 318-320o after sublimation at 200o/12mm. Purify it by preparative (2mm thick) TLC plates of silica gel, eluting with ethyl acetate/isopropanol/water (75:16:9, v/v; RF 0.75). The desired spot is localated with a uv lamp, cut the band from the plate, place it in MeOH, shake and filter it through a millipore filter, then evaporate. [Infante et al. J Chem Soc, Faraday Trans 1 68 1586 1973, Beilstein 24 H 353, 24 I 330, 24 II 183, 24 III/IV 1292.]티민 준비 용품 및 원자재
원자재
에틸알코올
요소
아세트산부틸
염산
아세트산(빙초산)
메틸알콜
메틸메타크릴레이트
1-(2-데옥시-β-D-리보피라노실)티민
5-메틸시토신
4(1H)-Pyrimidinone, 2-amino-5-methyl- (7CI,8CI,9CI)
2'-O-(2-메톡시에틸)-5-메틸우리딘
4-Hydroxy-5-methyl-2-mercaptopyrimidine
2,2'-안하이드로-5-메틸우리딘
디큐밀 퍼옥사이드
티미딘
우라실
시토신
준비 용품
티민 공급 업체
글로벌( 659)공급 업체
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