b-AP15
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b-AP15 속성
- 끓는 점
- 670.4±55.0 °C(Predicted)
- 밀도
- 1.416±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO에 용해됩니다(최대 35mg/ml).
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- -1.58±0.20(Predicted)
- 색상
- 옅은 노랑
- 안정성
- 최대 3개월 동안 -20°의 DMSO에 보관
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
b-AP15 C화학적 특성, 용도, 생산
효소 저해제
This deubiquitinase inhibitor (FW = 421.31 g/mol; CAS 1009817-63-3), also named 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)- (3E,5E)-4-piperidinone, targets two proteasome-associated ubiquitin carboxyl-terminal hydrolase-14, or USP14, and Ubiquitin Carboxyl-terminal Hydrolase isozyme L5 UCHL5, IC50 = 2.1 μM, resulting in a rapid accumulation of high-molecular-weight ubiquitin conjugates and functional shutdown of proteasome. Interestingly, b-AP15 displays several differences with respect to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in solid tumor models. Inhibition of DUBs blocked the processing and release of interleukin IL-1β in both mouse and human macrophages. DUB activity was necessary for inflammasome association as DUB inhibition also impaired ASC oligomerization and caspase-1 activation without directly blocking caspase- 1 activity. These data reveal the requirement for DUB activity in a key reaction of the innate immune response and highlight the therapeutic potential of DUB inhibitors for chronic auto-inflammatory diseases. (See also Bortezomib, Eeeyarestatin I)b-AP15 준비 용품 및 원자재
원자재
준비 용품
b-AP15 공급 업체
글로벌( 88)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24099 | 58 |
Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 |
sales@shengdapharm.com | CHINA | 310 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 |
shawn@hirisunpharm.com | CHINA | 9923 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8474 | 58 |
b-AP15 관련 검색:
NSC781406
2,4-Thiazolidinedione,5-[(4-hydroxy-3-methoxyphenyl)methylene]-
4-Chloro-N,N-diisopropylbenzamide
Pifithrin-μ
2-Pyridinecarbothioamide, N-2-pyridinyl-
1,3-Bis(4-aminophenyl)urea
5-(4-iodobenzylidene)rhodanine
S3I-201
NSC228155
NSC632839hydrochloride
NSC23005 Sodium
HAMNO
NSC 247030
5-[(4-chlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione
BAY 11-7082
TCID
1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone
TIMTEC-BB SBB006342