호스신 하이드로브로마이드
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호스신 하이드로브로마이드 속성
- 녹는점
- 195-199 °C (dry matter)(lit.)
- 알파
- D25 -24 to -26° (c = 5, calculated on anhydrous basis)
- 저장 조건
- Store at RT
- 용해도
- H2O: 50 mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- InChI
- InChI=1/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/s3
- InChIKey
- WTGQALLALWYDJH-MLRWSLNSNA-N
- SMILES
- [C@]12([H])O[C@@]1([H])[C@@]1([H])N(C)[C@]2([H])C[C@@H](OC(=O)[C@H](CO)C2C=CC=CC=2)C1.Br |&1:0,3,5,9,12,16,r|
- CAS 데이터베이스
- 114-49-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22 | ||
| 안전지침서 | 36 | ||
| 유엔번호(UN No.) | UN 1544 6.1/PG 1 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | YM4550000 | ||
| F 고인화성물질 | 3-8 | ||
| HS 번호 | 2939800000 | ||
| 독성 | LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick) |
호스신 하이드로브로마이드 C화학적 특성, 용도, 생산
개요
Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family. It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals. Scopolamine prevents motion sickness, nausea, and vomiting in animals.화학적 성질
Off-White Solid용도
An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant정의
ChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.일반 설명
Scopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.
공기와 물의 반응
Sensitive to air, light and moisture. Water soluble.반응 프로필
Scopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .화재위험
Flash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.생물학적 활성
Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.Clinical Use
A sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.Purification Methods
The hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]호스신 하이드로브로마이드 준비 용품 및 원자재
원자재
준비 용품
호스신 하이드로브로마이드 공급 업체
글로벌( 459)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3882 | 58 |
| Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 |
evan@tyvovo.com | China | 149 | 58 |
| ARCTIC EXPORTS INC | +1-3026880818 +1-3026880818 |
ARCTICEXPORTSINC@GMAIL.COM | Canada | 66 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29885 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2930 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
호스신 하이드로브로마이드 관련 검색:
피리딘 하이드로브로마이드 브롬화수소 스코폴레틴 4'-히드록시-2,4-디메톡시벤조페논
SCOPOLAMINE N-OXIDE HYDROBROMIDE
Scopolamine Hydrobromide Trihydrate
Scopolamine
Scopolamine butylbromide
(-)-SCOPOLAMINE
HYOSCINE HYDROCHLORIDE
DL-TROPIC ACID
Scopine
DL-(SCOPOLAMINE HYDROBROMIDE)
Cimetropium bromide
DEXTROMETHORPHAN HYDROBROMIDE
HYOSCINE N BUTYL BROMIDE BP
Methscopolamine bromide
SCOPOLAMINE-D3 HBR 3H2O (N-METHYL-D3)