ChemicalBook >제품 카탈로그 >천연 제품>플라보노이드>DEGUELIN

DEGUELIN

DEGUELIN 구조식 이미지

카스 번호:: 522-17-8

상품명:: DEGUELIN

동의어(영문):: DEGUELIN;Ccris 8104;()-Deguelin;(-)-DEGUELIN;(7as-cis)-oxy-;Deguelin (6CI);(-)-cis-Deguelin;(-)-cis-Deguelin;12a-DEOXYTEPHROSIN;(-)-DEGUELIN;(-)-CIS-DEGUELIN

CBNumber:: CB9431676

분자식:: C23H22O6

포뮬러 무게:: 394.42

MOL 파일:: 522-17-8.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 156

DEGUELIN 속성

녹는점: 85-87 °C(lit.)

끓는 점: 560.1±50.0 °C(Predicted)

알파: D27 -97.2° (c = 0.2 in benzene)

밀도: 1?+-.0.06 g/cm3(Predicted)

저장 조건: -20°C

용해도: DMSO: >10mg/mL

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 흰색에서 노란색으로

optical activity: [α]/D -70 to -80°, c = 0.2 in methanol

안정성: 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.

안전

안전지침서	22-24/25
WGK 독일	3
RTECS 번호	DX1500000
HS 번호	29329990

DEGUELIN C화학적 특성, 용도, 생산

개요

Rotenoids, deriving from the flavonoid family of compounds, act as chemopreventive agents that inhibit NADH:ubiquinone oxidoreductase activity and suppress phorbol ester-induced ornithine decarboxylase (ODC) activity. The rotenoid compound deguelin, originally isolated from the bark of M. sericea (Leguminosae) to be used as an insecticide and fish poison, has chemopreventive and chemosensitizing effects in models of skin, mammary, colon, and lung carcinogenesis. Deguelin inhibits cell growth (IC₅₀ = <10-8 M), blocks PI3K/Akt activation, suppresses COX-2 expression, and induces apoptosis in premalignant and squamous human bronchial epithelial (HBE) cells without affecting normal HBE cells. At 6 mg/kg, deguelin induces Parkinson’s disease-like symptoms in rats after six days of subcutaneous infusion and therefore may also serve as a useful model for Parkinson’s disease research.

용도

Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers.

생물학적 활성

Anticancer and antiviral agent; chemopreventive and pro-apoptotic. Inhibits phorbol ester-induced ornithine decarboxylase and NADH:ubiquinone oxidoreductase activities (IC 50 values are 11 and 6.9 nM respectively). Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo .

DEGUELIN 준비 용품 및 원자재

원자재

준비 용품

DEGUELIN 공급 업체

글로벌( 156)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3777	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49392	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29825	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	4088	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34571	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	info@afinechem.com	China	15395	58

DEGUELIN 관련 검색:

NS-398 Indometacin Piroxicam (S)-(+)-Ibuprofen Saw Palmetto P.E Heartleaf Houttuynia P.E. Meloxicam Elm bark extract Rotenone N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Equol DEGUELIN 4'-METHOXY-2-P-METHOXYPHENYLBUTYROPHENONE 1-(2,4-Dihydroxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone 2,5-DIMETHOXYPHENYLACETONE METHYLEUGENOLGLYCOL 5-HYDROXY-2,2-DIMETHYL-2H-CHROMENE-6-CARBALDEHYDE (2,4,5-TRIMETHOXYPHENYL)ACETALDEHYDE